Sökresultat - "variants"

Pharmacogenomic variants in the Pumi population from Yunnan, China.

Yang X; Department of blood transfusion, The First People's Hospital of Yunnan Province. The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, China., Cheng Y; Department of blood transfusion, The First People's Hospital of Yunnan Province. The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, China., Li Q; Department of blood transfusion, The First People's Hospital of Yunnan Province. The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, China., Chen W; Department of blood transfusion, The First People's Hospital of Yunnan Province. The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, China., Wang Y; Department of blood transfusion, The First People's Hospital of Yunnan Province. The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, China., Zhang C; Department of blood transfusion, The First People's Hospital of Yunnan Province. The Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, Yunnan, China. Electronic address: zhangchanyzt@163.com., Zhang X; Maternal and Child Health Service Center of Nujiang Autonomous Prefecture, Lushui 673599, Yunnan, China. Electronic address: 19863426@qq.com.

Journal Article , 2025

Investigation on the association between Osteopontin and Apolipoprotein E gene polymorphisms and vancomycin-induced acute kidney injury: A pharmacokinetic/pharmacogenetic study in critically ill patients.

Firouzabadi N; Department of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran., Karbasi D; Department of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran., Ghasemiyeh P; Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran., Sadeghi F; Department of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran., Alimoradi N; Department of Pharmacology & Toxicology, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran., Kavousi M; Department of Epidemiology, Erasmus MC University Medical Centre Rotterdam, Rotterdam, the Netherlands., Mohammadi-Samani S; Pharmaceutical Sciences Research Centre, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran. Electronic address: smsamani@sums.ac.ir.

Journal Article , 2025

Effects of SCT genetic polymorphisms on methotrexate concentrations and toxicities in Chinese children with acute lymphoblastic leukemia.

Li M; Department of Pediatrics, Beijing Shijitan Hospital, Capital Medical University, Beijing, China., Zhao DQ; Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.; Department of Clinical Pharmacy, College of Pharmacy, Capital Medical University, Beijing, China., Kong XY; Department of Pharmacy, Armed Police Beijing Corps Hospital, Beijing, China., Wang SM; Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University, Beijing, China.

Journal Article , 2025

Pharmacogenetic Profiling of Genes Associated with Outcomes of Chemotherapy in Omani Healthy Controls.

Al-Mahrouqi N; Research Laboratories, Sultan Qaboos Comprehensive Cancer Care & Research Centre, University Medical City, Muscat 123, Oman., Al Shuaili N; Research Laboratories, Sultan Qaboos Comprehensive Cancer Care & Research Centre, University Medical City, Muscat 123, Oman., Al-Zadjali S; Research Laboratories, Sultan Qaboos Comprehensive Cancer Care & Research Centre, University Medical City, Muscat 123, Oman., Pullanhi A; Research Laboratories, Sultan Qaboos Comprehensive Cancer Care & Research Centre, University Medical City, Muscat 123, Oman., Al-Barwani H; Research Laboratories, Sultan Qaboos Comprehensive Cancer Care & Research Centre, University Medical City, Muscat 123, Oman., Al-Kindy A; Clinical Trials Department, Sultan Qaboos Comprehensive Cancer Care & Research Centre, University Medical City, Muscat 123, Oman., Al-Sharqi H; Pharmacy Department, Sultan Qaboos Comprehensive Cancer Care & Research Centre, University Medical City, Muscat 123, Oman., Al-Baimani K; Department of Medical Oncology, Sultan Qaboos Comprehensive Cancer Care & Research Centre, University Medical City, Muscat 123, Oman., Al-Moundhri M; Department of Medical Oncology, Sultan Qaboos Comprehensive Cancer Care & Research Centre, University Medical City, Muscat 123, Oman., Salman B; Pharmacy Department, Omani National Hematology and Bone Marrow Transplant Center, University Medical City, Muscat 123, Oman.

Journal Article , 2025

Combining genetic proxies of drug targets and time-to-event analyses from longitudinal observational data to identify target patient populations.

Zhang L; Tenaya Therapeutics, South San Francisco, CA, USA., Kulkarni P; Tenaya Therapeutics, South San Francisco, CA, USA.; University of California San Diego, San Diego, CA, USA., Farshidfar F; Tenaya Therapeutics, South San Francisco, CA, USA., Tingley W; Tenaya Therapeutics, South San Francisco, CA, USA., Hoey T; Tenaya Therapeutics, South San Francisco, CA, USA., Wang W; Tenaya Therapeutics, South San Francisco, CA, USA., Priest JR; Tenaya Therapeutics, South San Francisco, CA, USA.; Department of Pediatrics, Stanford University, Stanford, CA, USA., Figarska SM; Tenaya Therapeutics, South San Francisco, CA, USA. sfigarska@tenayathera.com.

Journal Article; Observational Study , 2025

Cost-effectiveness of implementing a genotype-guided de-escalation strategy in patients with acute coronary syndrome.

van den Broek WWA; Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands., Azzahhafi J; Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands., Chan Pin Yin DRPP; Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands., van der Sangen NMR; Department of Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands., Sivanesan S; Department of Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands., Dijksman LM; Department of Value-Based Healthcare, St. Antonius Hospital, Nieuwegein, The Netherlands., Walhout RJ; Department of Cardiology, Hospital Gelderse Vallei, Ede, The Netherlands., Tjon Joe Gin M; Department of Cardiology, Rijnstate Hospital, Arnhem, The Netherlands., Breet NJ; Department of Cardiology, Gelre Hospitals, Apeldoorn, The Netherlands., Langerveld J; Department of Cardiology, Rivierenland Hospital, Tiel, The Netherlands., Vlachojannis GJ; Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands., van Bommel RJ; Department of Cardiology, Tergooi Hospital, Hilversum, The Netherlands., Appelman Y; Department of Cardiology, Amsterdam UMC, VU University, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands., van Schaik RHN; Department of Clinical Chemistry, Erasmus MC-University Medical Center, Rotterdam, The Netherlands., Henriques JPS; Department of Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands., Kikkert WJ; Department of Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Amsterdam, The Netherlands.; Department of Cardiology, Tergooi Hospital, Hilversum, The Netherlands., Ten Berg JM; Department of Cardiology, St. Antonius Hospital, Nieuwegein, The Netherlands.; Cardiovascular Research Institute Maastricht, University Medical Center Maastricht, Maastricht, The Netherlands.

Comparative Study; Journal Article; Observational Study , 2025

Impacts of Pharmacokinetic Gene Polymorphisms on Steady-State Plasma Concentrations of Simvastatin in Thai Population.

Tipnoppanon S; The Ph.D. Program in Clinical Biochemistry and Molecular Medicine, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand., Udomnilobol U; Chulalongkorn University Drug Discovery and Drug Development Research Center (Chula4DR), Chulalongkorn University, Bangkok, Thailand., Siwamogsatham S; Division of Ambulatory and Hospital Medicine, Department of Medicine, King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.; Chula Clinical Research Center (ChulaCRC), Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Vorasettakarnkij Y; Division of Ambulatory and Hospital Medicine, Department of Medicine, King Chulalongkorn Memorial Hospital, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Sukasem C; Division of Pharmacogenomics and Personalized Medicine, Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.; Laboratory for Pharmacogenomics, Somdech Phra Debaratana Medical Center (SDMC), Ramathibodi Hospital, Bangkok, Thailand., Prueksaritanont T; Chulalongkorn University Drug Discovery and Drug Development Research Center (Chula4DR), Chulalongkorn University, Bangkok, Thailand., Chariyavilaskul P; Center of Excellence in Clinical Pharmacokinetics and Pharmacogenomics, Chulalongkorn University, Bangkok, Thailand.; Department of Pharmacology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand., Yodsurang V; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.; Center of Excellence in Preclinical Toxicity and Efficacy Assessment of Medicines and Chemicals, Chulalongkorn University, Bangkok, Thailand., Srimatimanon T; Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand., Chamnanphon M; Department of Pathology, Faculty of Medicine, Srinakharinwirot University, Nakhonnayok, Thailand., Vanwong N; Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.

Journal Article , 2025

The Beta-Blocker Pharmacogenetic Puzzle: More Pieces of Evidence for Pharmacodynamic Candidate Variants.

Luzum JA; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA.; Center for Individualized and Genomic Medicine Research (CIGMA), Henry Ford Health System, Detroit, Michigan, USA., Littleton SDR; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA., Lopez-Medina AI; Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan, USA., Liu B; Center for Individualized and Genomic Medicine Research (CIGMA), Henry Ford Health System, Detroit, Michigan, USA., She R; Department of Public Health Sciences, Henry Ford Health System, Detroit, Michigan, USA., Lanfear DE; Center for Individualized and Genomic Medicine Research (CIGMA), Henry Ford Health System, Detroit, Michigan, USA.; Heart and Vascular Institute, Henry Ford Health System, Detroit, Michigan, USA.

Journal Article , 2025

The frequencies of CYP2C19*2, *3, and *17 alleles and their impact on the clinical efficacy of doubled maintenance dose of clopidogrel in Syrian patients with coronary artery disease.

Haj Saleh N; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus University, April 17th street, Al-Mazzeh, Damascus, Syria., A Youssef L; Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Damascus University, April 17th street, Al-Mazzeh, Damascus, Syria. ylama@hotmail.com.; National Commission for Biotechnology, Damascus, Syria. ylama@hotmail.com.

Journal Article , 2025

Genetic association of circulating lipids and lipid-lowering drug targets with vascular calcification.

Zhang P; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, 100091, China., Wang W; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, 100091, China., Xu Q; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, 100091, China., Cui J; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, 100091, China., Zhu M; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, 100091, China., Li Y; Experimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China., Liu Y; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, 100091, China; The Second Department of Gerontology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, 100091, China., Liu Y; National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Chinese Academy of Chinese Medical Sciences, Beijing, 100091, China. Electronic address: liuyueheart@hotmail.com.

Journal Article , 2025

Return of Clinically Actionable Pharmacogenetic Results From Molecular Tumor Board DNA Sequencing Data: Workflow and Estimated Costs.

Koo H; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Pharmacy Practice, Purdue University College of Pharmacy, West Lafayette, Indiana, USA., Smith TB; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA., Callaghan JT; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA., Osei W; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Pharmacy Practice, Purdue University College of Pharmacy, West Lafayette, Indiana, USA., Bray SM; LifeOmic, Inc., Indianapolis, Indiana, USA., Tillman EM; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA., Tran MT; Indiana University Health, Indianapolis, Indiana, USA., Fausel CA; Indiana University Health, Indianapolis, Indiana, USA., Schneider BP; Division of Hematology and Oncology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA., Shugg T; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA., Skaar TC; Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Journal Article , 2025

Genetic variants in tamoxifen metabolism and early treatment discontinuation among premenopausal breast cancer patients.

Woolpert KM; Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark. kwoolpert@clin.au.dk., Ahern TP; Department of Surgery, The Robert Larner, M.D. College of Medicine at the University of Vermont, Burlington, VT, USA., Baurley JW; BioRealm, Walnut, CA, USA., Maliniak ML; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Damkier P; Department of Clinical Pharmacology, Odense University Hospital, Odense, Denmark.; Department of Clinical Research, University of Southern Denmark, Odense, Denmark., Kjærsgaard A; Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark., Collin LJ; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA.; Department of Population Health Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA., Hamilton-Dutoit S; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark., Tramm T; Department of Pathology, Aarhus University Hospital, Aarhus, Denmark., Ejlertsen B; Danish Breast Cancer Group, Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Denmark.; Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Sørensen HT; Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark., Lash TL; Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA, USA., Cronin-Fenton DP; Department of Clinical Epidemiology, Department of Clinical Medicine, Aarhus University and Aarhus University Hospital, Aarhus, Denmark.

Journal Article , 2025

Lipid-lowering therapies for aortic stenosis: a drug-target Mendelian randomization study.

Ciofani JL; Sydney Medical School, The University of Sydney, Camperdown, NSW 2006, Australia.; Department of Cardiology, Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065, Australia.; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Exhibition Rd, South Kensington, London SW7 2AZ, UK., Han D; School of Mathematics and Statistics, University of New South Wales, Sydney 2052, Australia., Rao K; Sydney Medical School, The University of Sydney, Camperdown, NSW 2006, Australia.; Department of Cardiology, Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065, Australia., Gill D; Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, Exhibition Rd, South Kensington, London SW7 2AZ, UK., Woolf B; MRC Biostatistics Unit, University of Cambridge, Cambridge CB2 1TN, UK.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 1QU, UK.; School of Psychological Science, University of Bristol, Bristol BS8 1QU, UK., Rahimi K; Deep Medicine, Oxford Martin School, University of Oxford, Oxford OX1 2JD, UK.; Nuffield Department of Women's and Reproductive Health, Medical Science Division, University of Oxford, Oxford OX1 2JD, UK.; National Institute for Health Research Oxford Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, Oxford OX1 2JD, UK., Allahwala UK; Sydney Medical School, The University of Sydney, Camperdown, NSW 2006, Australia.; Department of Cardiology, Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065, Australia., Bhindi R; Sydney Medical School, The University of Sydney, Camperdown, NSW 2006, Australia.; Department of Cardiology, Royal North Shore Hospital, Reserve Road, St Leonards, NSW 2065, Australia.

Journal Article , 2025

Effect of ABCG2 c.421 C> A (rs2231142) single nucleotide polymorphisms on the lipid-modulating efficacy of rosuvastatin: a meta-analysis.

Liu L; Department of Medical Protection Center, The 926, Hospital of Joint Logistics Support Force of Chinesepeople'S Liberation Army, Kaiyuan, Yunan, China., Deng Y; Department of Medical Protection Center, The 926, Hospital of Joint Logistics Support Force of Chinesepeople'S Liberation Army, Kaiyuan, Yunan, China. 745763076@qq.com., Li P; Department of Clinical Laboratory, The 926, Hospital of Joint Logistics Support Force of Chinese People'S Liberation Army, Kaiyuan, Yunan, China., Zhang Z; Department of Cardiology, The 926, Hospital of Joint Logistics Support Force of Chinese People'S Liberation Army, Kaiyuan, Yunan, China., Li H; Department of Medical Protection Center, The 926, Hospital of Joint Logistics Support Force of Chinesepeople'S Liberation Army, Kaiyuan, Yunan, China., Yang X; Department of Medical Protection Center, The 926, Hospital of Joint Logistics Support Force of Chinesepeople'S Liberation Army, Kaiyuan, Yunan, China., Yin Z; Department of Medical Protection Center, The 926, Hospital of Joint Logistics Support Force of Chinesepeople'S Liberation Army, Kaiyuan, Yunan, China., Lai Y; Yunnan Provincial Key Laboratory of Entomological Biopharmaceutical R&D, Dali University, Dali, Yunnan Province, China. laiyong8879@163.com.; National-Local Joint Engineering Research Center of Entomoceutics, Dali University, Dali, Yunnan Province, China. laiyong8879@163.com.; College of Pharmacy Dali University, Dali, Yunnan, China. laiyong8879@163.com.

Journal Article; Meta-Analysis; Systematic Review , 2025

Association of antihypertensive drug target genes with stroke subtypes: A Mendelian randomization study.

Zheng H; School of Medicine, South China University of Technology, Guangzhou, China; Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China., Wang W; Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China., Qiu W; Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China., Feng Y; School of Medicine, South China University of Technology, Guangzhou, China; Department of Cardiology, Hypertension Research Laboratory, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, China. Electronic address: fengyingqing@gdph.org.cn.

Journal Article , 2025

Effects of FGF-related gene polymorphisms on cerebral infarction in patients treated with direct oral anticoagulants.

Kim JS; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea., Park M; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea., Park YA; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea., Lee DH; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea., Choi SA; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea., Jang EJ; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea., Yee J; School of Pharmacy, Sungkyunkwan University, Suwon 16419, Republic of Korea., Kim DH; Department of Cardiology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul 07804, Republic of Korea., Song TJ; Department of Neurology, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul 07804, Republic of Korea., Park J; Division of Cardiology, Ewha Womans University Mokdong Hospital, Ewha Womans University College of Medicine, Seoul 07985, Republic of Korea. Electronic address: parkjb@ewha.ac.kr., Gwak HS; College of Pharmacy, Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul 03760, Republic of Korea. Electronic address: hsgwak@ewha.ac.kr.

Journal Article; Research Support, Non-U.S. Gov't , 2025

Large-Scale Pharmacogenomics Analysis of Patients With Cancer Within the 100,000 Genomes Project Combining Whole-Genome Sequencing and Medical Records to Inform Clinical Practice.

Leong IUS; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Cabrera CP; Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; Centre for Translational Bioinformatics, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom., Cipriani V; Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, United Kingdom., Ross PJ; Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom., Turner RM; Wolfson Centre for Personalised Medicine, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, United Kingdom.; GSK, Stevenage, Hertfordshire, United Kingdom., Stuckey A; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Sanghvi S; Integrating Pharmacy & Medicines Optimisation Team, NHS North Central London Integrated Care System, UCLH NHS Foundation Trust, London., Pasko D; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Moutsianas L; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Odhams CA; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Elgar GS; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Chan G; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Giess A; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Walker S; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Foulger RE; SciBite Limited, BioData Innovation Centre, Wellcome Genome Campus, Hinxton, UK., Williams EM; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Daugherty LC; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Rueda-Martin A; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Rhodes DJ; BenevolentAI, London, United Kingdom., Niblock O; Cambridge Genomics Laboratory, United Kingdom., Pickard A; NHS England and NHS Improvement, London, United Kingdom., Marks L; NHS England and NHS Improvement, London, United Kingdom., Leigh SEA; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Welland MJ; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Bleda M; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Snow C; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Deans Z; NHS England and NHS Improvement, London, United Kingdom.; GenQA, Laboratory Medicine, NHS Lothian NINE, Edinburgh, United Kingdom., Murugaesu N; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom.; Guy's & St Thomas' NHS Foundation Trust, London, United Kingdom., Scott RH; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Barnes MR; Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, United Kingdom.; NIHR Barts Cardiovascular Biomedical Research Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.; Centre for Translational Bioinformatics, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom., Brown MA; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom.; Department of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom., Rendon A; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Hill S; NHS England and NHS Improvement, London, United Kingdom., Sosinsky A; Genomics England Ltd, Level 21 One Canada Square, London, United Kingdom., Caulfield MJ; Clinical Pharmacology and Precision Medicine, William Harvey Research Institute, Queen Mary University of London, Charterhouse Square, London, United Kingdom.; Faculty of Medicine and Dentistry, VP Health Office, Queen Mary University of London, London, United Kingdom., McDonagh EM; Open Targets, Wellcome Genome Campus, Hinxton, United Kingdom.; European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, United Kingdom.; Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom.

Journal Article , 2025

Phosphodiesterase 5 and its inhibitors with ischaemic heart disease: a Mendelian randomization analysis and a real-world study.

Xiao J; Department of Cardiovascular Surgery, Fujian Medical University, Union Hospital, Fuzhou, Fujian, China.; Heart Center of Fujian Medical University, Fuzhou, Fujian, China., Zhang N; Center for Primary Health Care Research, Department of Clinical Sciences Malmö, Lund University, Sweden.; Nutritional Epidemiology, Department of Clinical Sciences Malmö, Lund University, Malmö, Sweden., Gao Z; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China., Wei Y; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China., Wei H; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China., Qiu Z; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China., Sundquist K; Center for Primary Health Care Research, Department of Clinical Sciences Malmö, Lund University, Sweden., Sundquist J; Center for Primary Health Care Research, Department of Clinical Sciences Malmö, Lund University, Sweden., Ji J; Center for Primary Health Care Research, Department of Clinical Sciences Malmö, Lund University, Sweden.; Department of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Macao, Macao SAR, China., Huang W; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, Fujian, China.

Journal Article , 2025

Polygenic risk, aspirin, and primary prevention of coronary artery disease.

Yu C; Sc hool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC 3004, Australia., Natarajan P; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA., Patel AP; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02142, USA.; Cardiology Division, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.; Simches Research Center, Massachusetts General Hospital, Boston, MA 02114, USA., Bhatia HS; Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA., Khera AV; Division of Cardiology, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.; Verve Therapeutics, Boston, MA 02215, USA., Neumann JT; Sc hool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC 3004, Australia.; Department of Cardiology, University Heart & Vascular Center (UHZ), Hamburg 20251, Germany.; German Center for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, Hamburg 20251, Germany., Tsimikas S; Division of Cardiovascular Medicine, Department of Medicine, University of California San Diego, La Jolla, CA 92093, USA., Wolfe R; Sc hool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC 3004, Australia., Nicholls SJ; Sc hool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC 3004, Australia.; Victorian Heart Institute, Monash University, Clayton, VIC 3168, Australia., Reid CM; Sc hool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC 3004, Australia.; School of Population Health, Curtin University, Perth, WA 6102, Australia., Zoungas S; Sc hool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC 3004, Australia., Tonkin AM; Sc hool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC 3004, Australia., McNeil JJ; Sc hool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC 3004, Australia., Lacaze P; Sc hool of Public Health and Preventive Medicine, Monash University, 553 St Kilda Road, Melbourne, VIC 3004, Australia.

Journal Article; Randomized Controlled Trial; Multicenter Study , 2025

Pharmacogenomic profiling of variants affecting efficacy and toxicity of anti-infective medicines in a south Asian population from Sri Lanka.

Ranasinghe P; Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, 08, Sri Lanka. priyanga@pharm.cmb.ac.lk., Jeyapragasam H; Department of Pharmacology, Faculty of Medicine, University of Colombo, Colombo, 08, Sri Lanka., Sirisena N; Department of Anatomy, Genetics and Biomedical Informatics, Faculty of Medicine, University of Colombo, Colombo, 08, Sri Lanka., Bhagya Hendalage DP; Department of Anatomy, Genetics and Biomedical Informatics, Faculty of Medicine, University of Colombo, Colombo, 08, Sri Lanka., Dissanayake VHW; Department of Anatomy, Genetics and Biomedical Informatics, Faculty of Medicine, University of Colombo, Colombo, 08, Sri Lanka.

Journal Article , 2025