Prognostic Value of the Metabolic Response on Serial ¹⁸ F-FDG PET/CT in Pancreatic Cancer.

Gut and liver [Gut Liver] 2025 May 15; Vol. 19 (3), pp. 462-472. Date of Electronic Publication: 2025 Mar 07.

Background/aims: The prognostic value of serial ¹⁸ F-fluorodeoxyglucose positron emission tomography/ computed tomography ( ¹⁸ F-FDG PET/CT) for patients with borderline resectable or locally advanced pancreatic cancer who undergo conversion surgery or continue chemotherapy without surgery has not been well-established.
Methods: A retrospective analysis of patients with pancreatic ductal adenocarcinoma was conducted at Seoul National University Bundang Hospital between March 2013 and February 2022. Patients underwent PET/CT at baseline and subsequent radiologic evaluations following chemotherapy. Changes in the maximum standardized uptake value (SUVmax), mean standardized uptake value (SUVmean), metabolic tumor volume, and total lesion glycolysis were analyzed. Based on their treatment regimens, patients were stratified into the conversion surgery group or nonconversion surgery group. Survival outcomes and various clinical factors were assessed.
Results: Among 121 patients, 52 underwent conversion surgery, and 69 continued to receive chemotherapy without surgery. A significant reduction in the SUVmax was correlated with prolonged recurrence-free survival and overall survival in the conversion surgery group. Confirmation of a pathologic response indicated a significant association between reductions in the SUVmax and positive outcomes. Reductions in the metabolic tumor volume and total lesion glycolysis were associated with improved progression-free survival and overall survival in the nonconversion surgery group.
Conclusions: Serial PET/CT scans demonstrated prognostic value in pancreatic ductal adenocarcinoma patients, revealing distinct correlations in the conversion surgery group and nonconversion surgery group.

English

Publisher: Editorial Office of Gut and Liver Country of Publication: Korea (South) NLM ID: 101316452 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2005-1212 (Electronic) Linking ISSN: 19762283 NLM ISO Abbreviation: Gut Liver Subsets: MEDLINE

Positron Emission Tomography Computed Tomography*/methods , Pancreatic Neoplasms*/diagnostic imaging , Pancreatic Neoplasms*/mortality , Pancreatic Neoplasms*/metabolism , Pancreatic Neoplasms*/therapy , Pancreatic Neoplasms*/pathology , Pancreatic Neoplasms*/surgery , Fluorodeoxyglucose F18* , Carcinoma, Pancreatic Ductal*/diagnostic imaging , Carcinoma, Pancreatic Ductal*/mortality , Carcinoma, Pancreatic Ductal*/metabolism , Carcinoma, Pancreatic Ductal*/therapy, Humans ; Male ; Female ; Retrospective Studies ; Middle Aged ; Prognosis ; Aged ; Radiopharmaceuticals ; Adult

20250515