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Academic Journal
Establishing local diagnostic reference levels for adult whole-body PET/CT in Malaysia.
Al Said A, Rahman AA, Halim FNBA, Albadarneh L, Oglat AA, Saleh HH, Shloul W, Alshloul Y
Radiation protection dosimetry [Radiat Prot Dosimetry] 2025 Jun 05; Vol. 201 (8), pp. 568-576.
2025
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Title | Establishing local diagnostic reference levels for adult whole-body PET/CT in Malaysia. |
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Authors | Al Said A, Rahman AA, Halim FNBA, Albadarneh L, Oglat AA, Saleh HH, Shloul W, Alshloul Y |
Source |
Radiation protection dosimetry [Radiat Prot Dosimetry] 2025 Jun 05; Vol. 201 (8), pp. 568-576.
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Abstract |
Background: The combination of positron emission tomography (PET) and computed tomography (CT) scanning has significantly transformed the field of nuclear medicine.
Purpose: This study aims to establish local diagnostic reference levels (LDRLs) for adult positron emission tomography/computed tomography (PET/CT) scans utilizing three radiotracers:18F-fluorodeoxyglucose (18F-FDG), 68Gallium-prostate-specific-membrane-antigen (68Ga-PSMA), and 68Gallium-etraazacyclododecane-tetraacetic-acid-octreotide (68Ga-DOTATATE). Methods: Demographic data, radiation dose information, scanner PET/CT system specifications, and acquisition protocols were collected from the Department of Nuclear Medicine at Penang Hospital in Malaysia. The LDRL was determined by calculating the 50th percentile. Results: The proposed LDRLs values for whole-body 18F-FDG, 68Ga-PSMA and 68Ga-DOTATATE scans were 264 MBq, 194.07 MBq, and 186.85 MBq, respectively. The proposed LDRL for the diagnostic CT parameters (CTDIvol and DLP) associated with whole-body 18F-FDG PET/CT scans were 4.04 mGy and 412.25 mGy.cm, while proposed LDRL values for 68Ga-PSMA and 68Ga-DOTATATE scans were 4.33 mGy and 452.16 mGy.cm, and 4.51 mGy and 468.69 mGy.cm, respectively. Conclusion: The administered activity of 18F-FDG, 68Ga-PSMA, and 68Ga-DOTATATE examinations can be reduced without compromising or affecting the image quality. The proposed LDRL values for the CT parameters of the whole-body 18F-FDG examinations were the lowest among all compared values, but 68Ga-PSMA and 68Ga-DOTATATE examinations require further studies to optimize patient radiation doses in Malaysia and other regions while maintaining image quality. (© The Author(s) 2025. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.) |
Language |
English
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Journal Info |
Publisher: Oxford University Press Country of Publication: England NLM ID: 8109958 Publication Model: Print Cited Medium: Internet ISSN: 1742-3406 (Electronic) Linking ISSN: 01448420 NLM ISO Abbreviation: Radiat Prot Dosimetry Subsets: MEDLINE
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MeSH Terms |
Positron Emission Tomography Computed Tomography*/standards , Positron Emission Tomography Computed Tomography*/methods , Whole Body Imaging*/standards , Whole Body Imaging*/methods , Radiopharmaceuticals* , Organometallic Compounds*, Humans ; Malaysia ; Male ; Adult ; Middle Aged ; Female ; Fluorodeoxyglucose F18 ; Radiation Dosage ; Gallium Radioisotopes ; Aged ; Diagnostic Reference Levels ; Young Adult ; Gallium Isotopes
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Update Code |
20250606
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