A cross-sectional study on vitamin D deficiency and cardiac electrophysiology: Evaluating the frontal QRS-T angle.

Medicine [Medicine (Baltimore)] 2025 May 30; Vol. 104 (22), pp. e42694.

Competing Interests: The authors have no funding and conflicts of interest to disclose.
Vitamin D deficiency is a global health issue, primarily recognized for its role in bone health and calcium absorption. Emerging research has expanded its significance to cardiovascular health. This study aimed to assess the influence of vitamin D deficiency on the frontal QRS-T (f[QRS-T]) angle on electrocardiograms, a potential marker of arrhythmic risk and cardiac mortality, to address a notable gap in the current understanding. In this prospective cross-sectional study, 357 individuals were assessed, with 75 excluded (60 for not meeting criteria, 10 declined, 5 other reasons). A total of 282 participants were grouped by vitamin D levels: vitamin D-deficient (<20 ng/mL, n = 185) and non-deficient (≥20 ng/mL, n = 97). After excluding 7 participants for incomplete tests, data from 275 (deficient: n = 180; non-deficient: n = 95) were analyzed. Electrocardiograms were evaluated by a blinded cardiologist, and data were analyzed with appropriate statistical methods. Our analysis revealed no significant differences in the demographic characteristics, laboratory findings, and f(QRS-T) angle between the groups with and without vitamin D deficiency. This study indicated that vitamin D deficiency does not significantly affect the f(QRS-T) angle in our sample, suggesting a limited role of vitamin D status in the risk of ventricular arrhythmias. These findings contribute to the discussion on the role of vitamin D in cardiovascular health and underscore the need for further studies to guide clinical decisions regarding vitamin D supplementation and cardiovascular risk management.
(Copyright © 2025 the Author(s). Published by Wolters Kluwer Health, Inc.)

English

Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 2985248R Publication Model: Print Cited Medium: Internet ISSN: 1536-5964 (Electronic) Linking ISSN: 00257974 NLM ISO Abbreviation: Medicine (Baltimore) Subsets: MEDLINE

Vitamin D Deficiency*/physiopathology , Vitamin D Deficiency*/complications , Electrocardiography* , Arrhythmias, Cardiac*/etiology , Arrhythmias, Cardiac*/physiopathology, Humans ; Cross-Sectional Studies ; Male ; Female ; Middle Aged ; Prospective Studies ; Adult ; Vitamin D/blood ; Aged

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