江苏省15家医院极低/超低出生体重儿 抗生素使用现状调查. (Chinese)

Chinese Journal of Contemporary Pediatrics; Sep2022, Vol. 24 Issue 9, p988-993, 6p

VERY low birth weight, WEIGHT in infancy, NEONATAL intensive care units, BIRTH weight, GESTATIONAL age

Objective To investigate the current status of antibiotic use in very low birth weight/extremely low birth weight infants in Jiangsu Province of China, and to provide a clinical basis for the quality and improvement of antibiotic management in the neonatal intensive care unit (NICU). Methods A retrospective analysis was performed on the data on general conditions and antibiotic use in the very low birth weight/extremely low birth weight infants who were admitted to 15 hospitals of Jiangsu Province from January 1, 2019 to December 31, 2020. A questionnaire containing 10 measures to reduce antibiotic use was designed to investigate the implementation of these intervention measures. Results A total of 1 920 very low birth weight/extremely low birth weight infants were enrolled, among whom 1 846 (96.15%) were treated with antibiotic, and the median antibiotic use rate (AUR) was 50/100 patient-days. The AUR ranged from 24/100 to 100/100 patient-days in the 15 hospitals. After adjustment for the confounding factors including gestational age, birth weight, and neonatal critical score, the Poisson regression analysis showed that there was a significant difference in the adjusted AUR (aAUR) among the hospitals (P<0.01). The investigation results showed that among the 10 measures to reduce antibiotic use, 8 measures were implemented in less than 50% of these hospitals, and the number of intervention measures implemented was negatively correlated with aAUR (rs=-0.564, P=0.029). Conclusions There is a high AUR among the very low birth weight/extremely low birth weight infants in the 15 hospitals of Jiangsu Province, with a significant difference among hospitals. The hospitals implementing a relatively few measures to reduce antibiotic use tend to have a high AUR. It is expected to reduce AUR in very low birth weight/extremely low birth weight infants by promoting the quality improvement of antibiotic use management in the NICU. [ABSTRACT FROM AUTHOR]

目的调查并分析江苏省极低/超低出生体重儿抗生素使用现状, 为促进新生儿重症监护室 （neonatal intensive care unit, NICU） 抗生素管理质量及改进提供临床依据。方法回顾性分析2019 年1 月1 日至 2020 年12 月31 日江苏省15 家医院收治的极低/超低出生体重儿的一般情况及抗生素使用情况的相关资料, 并设 计减少抗生素使用措施的10 项调查问卷表, 通过问卷调查了解干预措施的实施情况。结果共纳入1 920 例极 低/超低出生体重儿, 其中1 846 例（96.15%） 使用抗生素, 抗生素使用率（antibiotic use rate, AUR） 中位数为 50/100 住院日。15 家医院AUR 为24~100/100 住院日。采用Poisson 回归, 调整胎龄、出生体重、新生儿危重评分 混杂因素后, 各医院间调整后抗生素使用率（adjusted antibiotic use rate, aAUR） 差异有统计学意义（P<0.01）。 调查结果显示, 10 项减少抗生素使用的措施中, 8 项措施开展的医院不足一半;干预措施实施项目数与aAUR 呈 负相关（rs=-0.564, P=0.029）。结论江苏省15 家医院极低/超低出生体重儿AUR 高, 且医院之间差异大;实施 减少抗生素使用措施少的医院AUR 高, 促进NICU 抗生素使用管理的质量改进, 有望减少极低/超低出生体重儿 的AUR. [ABSTRACT FROM AUTHOR]

Copyright of Chinese Journal of Contemporary Pediatrics is the property of Xiangya Medical Periodical Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)