食源性蛋白酪氨酸磷酸酶1B抑制剂的功能意义 和结构-活性关系. (Chinese)

Shipin Kexue/ Food Science; 2023, Vol. 44 Issue 17, p258-267, 10p

PROTEIN-tyrosine phosphatase, PHOSPHOPROTEIN phosphatases, TYPE 2 diabetes, LEPTIN, INSULIN receptors, DIABETES complications, NATURAL products

Protein tyrosine phosphatase 1B (PTP1B), a potential target for the treatment of type 2 diabetes and obesity, plays a key negative regulatory role in the insulin and leptin signaling pathways. Natural products, with structural diversity, can affect different targets and pathways to exert their unique preventive and therapeutic effects on diabetes or its complications. Various food-derived natural products have been reported for their PTP1B inhibitory activity in recent years. This article mainly overviews recent progress in understanding the mechanism of action of PTP1B and food-derived natural PTP1B inhibitors, which will hopefully provide a theoretical rationale for further research on PTP1B inhibitors and the development of new PTP1B inhibitors or hypoglycemic functional foods. [ABSTRACT FROM AUTHOR]

蛋白酪氨酸磷酸酶1B（protein tyrosine phosphatase 1B, PTP1B）在胰岛素和瘦素信号通路中发挥着关键的 负调节作用, 是治疗2型糖尿病和肥胖症的潜在靶点。天然产物因其结构的多样性, 能够针对不同的靶点和途径对 糖尿病或其并发症发挥独特的预防和治疗效果。近年来, 多种食源性天然产物已被报道具有PTP1B抑制活性。本文 主要就PTP1B的作用机制和食源性天然PTP1B抑制剂的研究进展进行了综述, 以期为进一步开展PTP1B抑制剂的研 究工作以及开发新型PTP1B抑制剂或降糖功能食品提供参考。 [ABSTRACT FROM AUTHOR]

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