蓝靛果花青素复合液态制剂对Ⅱ型糖尿病 小鼠糖脂代谢的影响. (Chinese)

Science & Technology of Food Industry; Sep2024, Vol. 45 Issue 18, p308-316, 9p

TYPE 2 diabetes, BLOOD sugar, LIPID metabolism, INSULIN resistance, COMPLEX fluids

Objective: Investigate the effects of Lonicera caerulea anthocyanin complex liquid preparation (compound made of Lonicera caerulea L., Polygonatum sibiricum, Inonotus obliquus, LPI) on glucose and lipid metabolism in type 2 diabetes mellitus (T2D) mice. Methods: T2D model in mice was constructed by high-fat feeding combined with streptozotocin. The mice were randomly divided into 6 groups: Blank control group, diabetes model group, low, middle and high dose sample group and metformin positive control group. After continuous intervention for 28 days, the body mass data and physiological and biochemical indexes of mice were measured and recorded, and the pathological observation of the organs of mice was performed. Results: Each dose group of LPI could increase the weight of T2D mice, improve the symptoms of organ injury, significantly reduce serum insulin level (P<0.05) and significantly increase the levels of HDL-C (P<0.05). Each dose group of LPI could significantly reduce fasting blood glucose (P<0.05) as well as insulin resistance index (P<0.05), improve glucose tolerance (P<0.05), and reduce the levels of TC, TG and LDL-C in serum of T2D mice (P<0.05) in a dose-dependent manner. [ABSTRACT FROM AUTHOR]

目的; 探究蓝靛果花青素复合液态制剂 (由 Lonicera caerulea L.、Polygonatum sibiricum、Inonotus obliquus 复配制成, LPI) 对Ⅱ型糖尿病 (T2D) 小鼠糖脂代谢的影响. 方法; 高脂饲喂结合链脲佐菌素诱导构建 T2D 小鼠模型, 将其随机分为 6 组进行饲养; 空白对照组、糖尿病模型组、低中高剂量样品组和二甲双胍阳性对 照组. 28 d 连续干预后测定并记录小鼠的体质量数据及生理生化指标, 并对小鼠的脏器进行病理学观察. 结果; LPI 各个剂量组均能升高 T2D 小鼠体重, 改善脏器损伤的症状, 显著降低血清胰岛素水平 (P<0.05) 并显著提高 HDL-C 水平 (P<0.05) . LPI 各个剂量组可以显著降低空腹血糖值 (P<0.05) 及胰岛素抵抗指数 (P<0.05), 改 善其葡萄糖耐量 (P<0.05), 并使 T2D 小鼠血清 TC、TG、LDL-C 水平显著降低, 且具有剂量依赖性. 结论; 蓝 靛果花青素复合液态制剂可从体质量数据、糖代谢、脏器病理损伤、脂代谢多方面改善 T2D 小鼠的代谢紊乱情 况, 为新型天然植物降糖制剂的研发及糖尿病防治提供理论支撑. [ABSTRACT FROM AUTHOR]

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