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Academic Journal
PLEIOTROPIC EFFECTS OF PARATHYROIDECTOMY AND AGONIST CALCIUM-SENSITIVE RECEPTOR, CINACALCET
L. V. Egshatyan, L. Ya. Rozhinskaya, N. S. Kuznetsov, M. Sh. Shamkhalova
Рациональная фармакотерапия в кардиологии, Vol 9, Iss 2, Pp 152-157 (2015)
Sparad:
| Titel | PLEIOTROPIC EFFECTS OF PARATHYROIDECTOMY AND AGONIST CALCIUM-SENSITIVE RECEPTOR, CINACALCET |
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| Författarna | L. V. Egshatyan, L. Ya. Rozhinskaya, N. S. Kuznetsov, M. Sh. Shamkhalova |
| Utgivningsår |
2015
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| Källa |
Рациональная фармакотерапия в кардиологии, Vol 9, Iss 2, Pp 152-157 (2015)
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| Beskrivning |
Aim. To evaluate the effect of parathyroidectomy and cinacalcet on anemia, lipid profile and blood pressure (BP) in uremic hyperparathyroidism.Material and methods. Uremic patients (n=39) treated with hemodialysis and having secondary hyperparathyroidism were included into the study. Radical parathyroidectomy was performed in 21 patients, 18 patients were treated with cinacalcet. BP measurement, determination of blood levels of albumin, total calcium, phosphorus, total cholesterol (TC), low (LDL) and high density lipoproteins, triglycerides, intact parathyroid hormone, and hemoglobin were performed in all patients initially and during treatment. Doses of antihypertensive and erythropoiesis-stimulating agents were also assessed.Results. Calcium-phosphorus metabolism indices improved after 6 months of cinacalcet therapy and parathyroidectomy (pConclusion. The pleiotropic effects (reduction in BP and atherogenic lipids levels, as well as decrease in anemia resistant to the action of erythropoiesis-stimulating agents) were found after parathyroidectomy and cinacalcet therapy additionally to calcium-phosphorus metabolism improvement.
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| Dokumenttyp |
article
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| Språk |
English
Russian |
| Information om utgivare |
Столичная издательская компания, 2015.
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| Ämnestermer | |
