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Academic Journal

Impact of radiation response on survival in pediatric medulloblastoma with residual or disseminated disease

Xuejiao Shi, Xiaoyang Sun, Wenqi Fan, Xuan Dai, Mawei Jiang

Radiation Oncology, Vol 20, Iss 1, Pp 1-9 (2025)

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Titel Impact of radiation response on survival in pediatric medulloblastoma with residual or disseminated disease
Författarna Xuejiao Shi, Xiaoyang Sun, Wenqi Fan, Xuan Dai, Mawei Jiang
Utgivningsår
2025
Källa
Radiation Oncology, Vol 20, Iss 1, Pp 1-9 (2025)
Beskrivning
Abstract Background This study aimed to determine the clinical impact of radiation response on survival in patients with medulloblastoma (MB) and to explore the predictive factor of radiation response. Methods Data from 170 pediatric patients with MB and residual disease or metastasis before radiotherapy (RT) were analyzed. Results The median follow-up period was 5.2 years. A total of 74 (43.5%) patients achieved CR, 85 (50.0%) patients achieved PR, 8 (4.7%) patients had SD, and 3 (1.8%) patients developed PD after RT. The five-year post-RT progression-free (prtPFS) and overall survival (prtOS) were superior in patients who achieved CR compared to those who did not (prtPFS: 67% ± 6% vs. 42% ± 6%, P
Dokumenttyp
article
Språk
English
Information om utgivare
BMC, 2025.
Ämnestermer
Medulloblastoma, Radiation response, Prognosis, Predictive factor, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
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