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Academic Journal
FIBROBLAST GROWTH FACTOR 23 AND KLOTHO PROTEIN IN THE PATHOGENESIS OF SECONDARY HYPERPARATHYROIDISM
A V Ilin, M I Arbuzova
Остеопороз и остеопатии, Vol 16, Iss 3, Pp 20-27 (2013)
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| Title | FIBROBLAST GROWTH FACTOR 23 AND KLOTHO PROTEIN IN THE PATHOGENESIS OF SECONDARY HYPERPARATHYROIDISM |
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| Authors | A V Ilin, M I Arbuzova |
| Publication Year |
2013
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| Source |
Остеопороз и остеопатии, Vol 16, Iss 3, Pp 20-27 (2013)
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| Description |
One of the main problems in patients with chronic kidney disease (CKD) is a disturbance of calcium-phosphorus metabolism, especially in chronic hemodialysis. Besides classical endocrine axis parathyroid-kidney, in recent years was established the existence of a new endocrine axis the bone-kidney, which gives a better explanation of the calcium and phosphorus metabolism abnormalities, pathophysiology of secondary hyperparathyroidism in CKD. FGF23 is a circulating factor synthesized in osteocytes. It inhibits renal phosphate reabsorption and activity of 1-alphahydroxylase. Anti-aging Klotho protein is a potent co-factor of FGF23. This review presents the mechanisms of the interaction of these elements of the newly discovered axis in normal settings and secondary hyperparathyroidism.
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| Document Type |
article
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| Language |
English
Russian |
| Publisher Information |
Endocrinology Research Centre, 2013.
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| Subject Terms | |
