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Academic Journal
THE EFFECT OF NEBIVOLOL ON BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN WITH MILD HYPERTENSION
I. L. Tepoyan, D. V. Nebieridze, I. A. Skripnikova, A. S. Safaryan, V. A. Vygodin, V. E. Novikov, L. M. Murashko
Рациональная фармакотерапия в кардиологии, Vol 11, Iss 3, Pp 293-296 (2015)
Sparad:
| Titel | THE EFFECT OF NEBIVOLOL ON BONE MINERAL DENSITY IN POSTMENOPAUSAL WOMEN WITH MILD HYPERTENSION |
|---|---|
| Författarna | I. L. Tepoyan, D. V. Nebieridze, I. A. Skripnikova, A. S. Safaryan, V. A. Vygodin, V. E. Novikov, L. M. Murashko |
| Utgivningsår |
2015
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| Källa |
Рациональная фармакотерапия в кардиологии, Vol 11, Iss 3, Pp 293-296 (2015)
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| Beskrivning |
Aim. To study the effects of nebivolol on bone mineral density (BMD) in postmenopausal women with mild hypertension (HT) and osteopenia.Material and methods. Postmenopausal women (n=56) aged 50-65 years with mild HT фтв osteopenia were included into the randomized controlled study and divided in two groups (28 patients in each). During 12 months patients of the main group received treatment with nebivolol (5-7.5 mg/day) and patients of the control group received treatment with atenolol (12.5-25 mg/day). Clinical and anthropometric examinations, blood pressure measurements, ECG registrations were performed in all patients initially and after 12 months of treatment. Quantitative estimation of BMD was performed by dual energy X-ray absorptiometry with osteodensitometry DELPHI W manufactured by HOLOGIC company (USA) in the lumbar spine (L1-L4), femoral neck and proximal femur in the anterior-posterior projection. In addition, calcium and bone metabolism indices were determined: ionized calcium, total alkaline phosphatase, C-telopeptide of type I collagen (CTX).Results. Therapy of mild HT with nebivolol during 12 months showed increase in BMD in the spine according to the T-test from -1.7±0.4 SD to -1.4±0.53 SD (pConclusion. The study demonstrated the positive effect of nebivolol on BMD, whereas atenolol had no effect on bone mass.
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| Dokumenttyp |
article
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| Språk |
English
Russian |
| Information om utgivare |
Столичная издательская компания, 2015.
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| Ämnestermer | |
