gastric adenocarcinoma, ywhaq, clinicopathologic features, prognosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

ObjectiveTo investigate the expression of YWHAQ protein in gastric adenocarcinoma tissues and its correlation with clinical pathological features and prognosis. MethodsA total of 127 patients with gastric cancer who underwent radical surgery were enrolled. Clinical data and postoperative cancer tissue samples were collected from the patients. Immunohistochemistry was used to detect the protein expression of YWHAQ in gastric adenocarcinoma tissues. The relationship between YWHAQ expression and clinical pathological features and prognosis was analyzed. Bioinformatics prediction was performed to identify potential pathways regulated by YWHAQ in gastric adenocarcinoma. A protein-protein interaction network for YWHAQ was constructed using the STRING database. ResultsYWHAQ gene expression was significantly higher in gastric adenocarcinoma tissues than in normal tissues (P1, P