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Academic Journal
Prognostic Value of an Immunohistochemical Signature in Patients With Head and Neck Mucosal Melanoma
Qing-Qing Xu, Qing-Jie Li, Cheng-Long Huang, Mu-Yan Cai, Mei-Fang Zhang, Shao-Han Yin, Li-Xia Lu, Lei Chen
Frontiers in Immunology, Vol 12 (2021)
Sparad:
| Titel | Prognostic Value of an Immunohistochemical Signature in Patients With Head and Neck Mucosal Melanoma |
|---|---|
| Författarna | Qing-Qing Xu, Qing-Jie Li, Cheng-Long Huang, Mu-Yan Cai, Mei-Fang Zhang, Shao-Han Yin, Li-Xia Lu, Lei Chen |
| Utgivningsår |
2021
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| Källa |
Frontiers in Immunology, Vol 12 (2021)
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| Beskrivning |
PurposeWe aimed to develop a prognostic immunohistochemistry (IHC) signature for patients with head and neck mucosal melanoma (MMHN).MethodsIn total, 190 patients with nonmetastatic MMHN with complete clinical and pathological data before treatment were included in our retrospective study.ResultsWe extracted five IHC markers associated with overall survival (OS) and then constructed a signature in the training set (n=116) with the least absolute shrinkage and selection operator (LASSO) regression model. The validation set (n=74) was further built to confirm the prognostic significance of this classifier. We then divided patients into high- and low-risk groups according to the IHC score. In the training set, the 5-year OS rate was 22.0% (95% confidence interval [CI]: 11.2%- 43.2%) for the high-risk group and 54.1% (95% CI: 41.8%-69.9%) for the low-risk group (P
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| Dokumenttyp |
article
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| Språk |
English
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| Information om utgivare |
Frontiers Media S.A., 2021.
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| Ämnestermer | |
