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Academic Journal
Changes of blastogenic response of lymphoid cells in kindled animals under the influence of pentoxiphyllin
Е V Kobolev, V V Desyatsky, L S Godlevsky, V F Mustyatsu, G А Drozdova
RUDN Journal of Medicine, Vol 0, Iss 2, Pp 5-9 (2010)
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| Title | Changes of blastogenic response of lymphoid cells in kindled animals under the influence of pentoxiphyllin |
|---|---|
| Authors | Е V Kobolev, V V Desyatsky, L S Godlevsky, V F Mustyatsu, G А Drozdova |
| Publication Year |
2010
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| Source |
RUDN Journal of Medicine, Vol 0, Iss 2, Pp 5-9 (2010)
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| Description |
Under condition of acute experiments on male Wistar rats it was shown that under condition of kindling formation induced via repeated subthreshold corazol administration (30,0 mg/kg, i.p.) the decreasing of blastogenic response induced by bacterial lypopolysaccharide and phytogemagglutinin was shown. This effect was detectable after 10-th convulsant injection and intensified in the course of kindling (21 injections of picrotoxin). Pentoxiphyllin (25,0 and 50,0 mg/kg, i.p.) caused antiseizure effects and effectively prevented kindling-induced decreasing of blastogenic response in dose-depended manner.
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| Document Type |
article
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| Language |
English
Russian |
| Publisher Information |
Peoples’ Friendship University of Russia (RUDN University), 2010.
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| Subject Terms | |
