Регуляторные исследования и экспертиза лекарственных средств, Vol 0, Iss 4, Pp 20-27 (2018)

Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’), 2018.

преэклампсия, эндотелиальная дисфункция, ишемическое прекондиционирование, фармакологическое прекондиционирование, цитопротекция, preeclampsia, endothelial dysfunction, ischemic preconditioning, pharmacological preconditioning, cytoprotection, Medicine (General), R5-920

Preeclampsia is a frequent and dangerous disease in pregnancy which has shown no decrease in incidence. The article describes preeclampsia pathogenesis as reported in recent studies. A promising trend in the development of new medicines aimed at prevention and treatment of preeclampsia is the activation of biological processes of cytoprotection which arise during ischemic preconditioning. The article cites experimental and clinical data that help to justify the good potential of this area of research.