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Academic Journal
Search selective blockers of the zinc-dependent metalloproteinases 2nd and 9th type among the benzoylamino (phenylsulfonyl) amino-substituted cyclic aminoacids derivatives
S. A. Kryzhanovskii, G. V. Mokrov, O. S. Grigorkevich, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, A. M. Likhosherstov, T. A. Gudasheva
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 3-8 (2016)
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| Title | Search selective blockers of the zinc-dependent metalloproteinases 2nd and 9th type among the benzoylamino (phenylsulfonyl) amino-substituted cyclic aminoacids derivatives |
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| Authors | S. A. Kryzhanovskii, G. V. Mokrov, O. S. Grigorkevich, I. B. Tsorin, V. N. Stolyaruk, M. B. Vititnova, A. M. Likhosherstov, T. A. Gudasheva |
| Publication Year |
2016
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| Source |
Фармакокинетика и Фармакодинамика, Vol 0, Iss 3, Pp 3-8 (2016)
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| Description |
The purpose of this study - search among the benzoylamino (phenyLsuLfonyL) amino-substituted cyclic aminoacids derivatives biologically active compounds exhibiting properties of the zinc-dependent metaLLproteinases 2nd and 9th type blockers which is known to pLay a key roLe in the pathogenesis of the myocardium earLy post-infarction remodeLing. In studying the effect of newLy synthesized compounds on metaLLoproteinase-9 LeveLs in bLood of rats with acute myocardiaL infarction were seLected compound Leader: 1-({4-[(4-chLorobenzoyL)amino]phenyL}suLfonyL-L-proLine, which effectiveLy bLocked the increase of this enzyme Level. Using echocardiography it was demonstrated that the seLected compound-Leader prevents the myocardiaL remodeLing deveLopment in the acute phase of experimentaL myocardiaL infarction, at Least not inferior to the reference inhibitor of metaLLoproteinases - doxycycLine.
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| Document Type |
article
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| Language |
Russian
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| Publisher Information |
LLC “Publisher OKI”, 2016.
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| Subject Terms |
металлопротеиназы 2-го и 9-го типа, постинфарктное ремоделирование миокарда, производные бензоила-мино(фенилсульфонил)-замещённых циклических аминокислот, metallproteinases 2nd- and 9th-type, post-infarction myocardial remodeling, derivatives of the benzoylamino (phenylsulfonyl) amino-substituted cyclic aminoacids, Pharmacy and materia medica, RS1-441
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