Effects of intracranial pressure monitoring in pediatric severe traumatic brain injury: a meta-analysis of cohort studies

2025

Frontiers in Neurology, Vol 16 (2025)

IntroductionAs Severe traumatic brain injury (TBI) is a major cause of pediatric morbidity and mortality. The clinical benefits of intracranial pressure (ICP) monitoring in pediatric TBI remain debated. This meta-analysis aims to assess the impact of ICP monitoring on outcomes in children with severe TBI.MethodsFollowing PRISMA guidelines, a comprehensive search was conducted in PubMed, EMBASE, Cochrane Library, and Web of Science. Studies comparing pediatric severe TBI patients with and without ICP monitoring were included. Primary outcomes included in-hospital mortality and complications, while secondary outcomes included craniotomy/craniectomy rate, length of hospital stay and ICU stay, mechanical ventilation duration, and medical costs. Quality assessment was performed using the Methodological Index for Non-Randomized Studies (MINORS) for cohort studies. The weighted mean difference (WMD) for continuous variables and odds ratio (OR) for dichotomous variables were calculated, along with 95% confidence intervals (CIs). Meta-analysis was performed using RevMan 5.4.1 software.ResultsEight studies (12,987 patients) were included. ICP monitoring showed no significant impact on overall in-hospital mortality (OR, 1.14; p = 0.65), though propensity score matching (PSM) studies indicated a lower mortality rate with ICP monitoring (OR, 0.62; p = 0.005). However, ICP monitoring was associated with higher risks of infection-related (OR, 7.21; p < 0.001) and respiratory complications (OR, 5.79; p < 0.001), thromboembolic events (OR, 5.37; p < 0.001), increased craniotomy/craniectomy rates (OR, 2.34; P = 0.01), longer hospital (OR, 12.00; p < 0.001) and ICU stays (OR, 7.82; p < 0.001), extended mechanical ventilation durations (OR, 5.82; p < 0.001), and higher medical costs (WMD, 10.49; p = 0.006).ConclusionThis meta-analysis found no overall reduction in in-hospital mortality with ICP monitoring in pediatric severe TBI, potentially due to baseline severity imbalances in retrospective studies. However, PSM studies suggest a mortality benefit, indicating that ICP monitoring may be effective when confounding is minimized. Increased complication risks, longer hospital/ICU stays, prolonged ventilation, and higher costs were associated with monitoring, though these may reflect injury severity rather than monitoring itself. Given the limitations of this study, these findings should be interpreted cautiously.

article

English

Frontiers Media S.A., 2025.

intracranial pressure monitoring, severe traumatic brain injury, pediatric, mortality, complications, meta-analysis, Neurology. Diseases of the nervous system, RC346-429