Background: Single-balloon enteroscopy (SBE) is an effective tool in management of small-bowel disease. However, data on SBE in elderly patients are limited. In this study, we aimed to evaluate the safety, efficacy, and diagnostic and therapeutic utility of SBE in elderly patients. Methods: A retrospective review was performed at a tertiary referral hospital. A total of 168 patients who underwent 265 SBE procedures from December 2009 to October 2016 were included. Patients were divided into 2 groups based on age: young (