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Evaluation of effectiveness of solvent-detergent viral in activation in the manufacture of intravenous human immunoglobulin G in a model of virus diarrhea — mucosal disease of cattle
A V Kaz’yanin, N V Zubkova, I V Krasilnikov, A K Lobastova, V V Anastasiev, A M Nikolaeva, T I Glotova, O V Kungurtseva, A G Glotov
RUDN Journal of Medicine, Vol 0, Iss 4, Pp 24-30 (2013)
Sparad:
| Titel | Evaluation of effectiveness of solvent-detergent viral in activation in the manufacture of intravenous human immunoglobulin G in a model of virus diarrhea — mucosal disease of cattle |
|---|---|
| Författarna | A V Kaz’yanin, N V Zubkova, I V Krasilnikov, A K Lobastova, V V Anastasiev, A M Nikolaeva, T I Glotova, O V Kungurtseva, A G Glotov |
| Utgivningsår |
2013
|
| Källa |
RUDN Journal of Medicine, Vol 0, Iss 4, Pp 24-30 (2013)
|
| Beskrivning |
In model experiments using in vitro virus diarrhea — mucosal disease in cattle (bovine VD-MDC) studied the effectiveness of solvent-detergent (SD) virus inactivation used in the production of intravenous human immunoglobulin G (IgG). Optimized conditions for SD processing of immunoglobulin: the final concentration of tributylphosphate (TBP) 0.3% 0.2% sodium cholate, process temperature of 30 ± 1 °C to 36 ± 1 °C, incubation time 6 hours. The level of reduction of VD-MDC in the processing of the drug in these conditions was more than 6 log 10 TCD 50/ml.
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| Dokumenttyp |
article
|
| Språk |
English
Russian |
| Information om utgivare |
Peoples’ Friendship University of Russia (RUDN University), 2013.
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| Ämnestermer | |
