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A novel anoikis-related gene signature predicts prognosis in patients with sepsis and reveals immune infiltration

Yonghua Wang, Yanqi Chi, Cheng Zhu, Yuxuan Zhang, Ke Li, Jiajia Chen, Xiying Jiang, Kejie Chen, Shuping Li

Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)

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Bibliographic Details
Title A novel anoikis-related gene signature predicts prognosis in patients with sepsis and reveals immune infiltration
Authors Yonghua Wang, Yanqi Chi, Cheng Zhu, Yuxuan Zhang, Ke Li, Jiajia Chen, Xiying Jiang, Kejie Chen, Shuping Li
Publication Year
2024
Source
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Description
Abstract Sepsis is a common acute and severe medical condition with a high mortality rate. Anoikis, an emerging form of cell death, plays a significant role in various diseases. However, the role of anoikis in sepsis remains poorly understood. Based on the datasets from Gene Expression Omnibus and anoikis-related genes from GeneCards, the differentially expressed anoikis-related genes (DEARGs) were identified. Based on hub genes of DEARGs, a novel prognostic risk model was constructed, and the pattern of immune infiltration was investigated by CIBERSORT algorithm. And small molecule compounds targeting anoikis in sepsis were analyzed using Autodock. Of 23 DEARGs, CXCL8, CFLAR, FASLG and TP53 were significantly associated with the prognosis of sepsis (P
Document Type
article
Language
English
Publisher Information
Nature Portfolio, 2024.
Subject Terms
Medicine, Science
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