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Academic Journal
Genome‐wide meta‐analyses identify five new risk loci for nonsyndromic orofacial clefts in the Chinese Han population
Yafen Yu, Qi Zhen, Weiwei Chen, Yanqin Yu, Zhuo Li, Yirui Wang, Wencheng Fan, Sihan Luo, Daiyue Wang, Yuanming Bai, Zhuan Bian, Miao He, Liangdan Sun
Molecular Genetics & Genomic Medicine, Vol 11, Iss 10, Pp n/a-n/a (2023)
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| Title | Genome‐wide meta‐analyses identify five new risk loci for nonsyndromic orofacial clefts in the Chinese Han population |
|---|---|
| Authors | Yafen Yu, Qi Zhen, Weiwei Chen, Yanqin Yu, Zhuo Li, Yirui Wang, Wencheng Fan, Sihan Luo, Daiyue Wang, Yuanming Bai, Zhuan Bian, Miao He, Liangdan Sun |
| Publication Year |
2023
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| Source |
Molecular Genetics & Genomic Medicine, Vol 11, Iss 10, Pp n/a-n/a (2023)
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| Description |
Abstract Background Nonsyndromic orofacial clefts (NSOFCs) are the most common craniofacial birth malformations in humans and are generally classified as nonsyndromic cleft lip with or without cleft palate (NSCL/P) and nonsyndromic cleft palate only (NSCPO). Genome‐wide association studies (GWASs) of NSOFCs have demonstrated multiple risk loci and candidate genes; however, published risk factors are able to explain only a small fraction of the observed NSOFCs heritability. Methods Here, we performed GWASs of 1615 NSCPO cases and 2340 controls, and then conducted genome‐wide meta‐analyses of NSOFCs, totaling 6812 NSCL/P cases, 2614 NSCPO cases, and 19,165 controls from the Chinese Han population. Results We identify 47 risk loci with genome‐wide pmeta‐value
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| Document Type |
article
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| Language |
English
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| Publisher Information |
Wiley, 2023.
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| Subject Terms | |
