Prognostic value of advanced lung cancer inflammation index in heart failure patients: A comprehensive analysis

2025

ESC Heart Failure, Vol 12, Iss 3, Pp 2298-2309 (2025)

Abstract Aims The prognosis of heart failure (HF) is closely linked to inflammation and nutritional status. The advanced lung cancer inflammation index (ALI) is a composite indicator consisting of several parameters used to assess inflammation and nutritional status. Our study aimed to investigate the prognostic value of ALI in HF patients. Methods The data from Study 1, which included 1359 HF patients, were extracted from the National Health and Nutrition Examination Survey (NHANES) database spanning the years 1999 to 2018. Study 2 analysed data from patients with HF who underwent cardiac magnetic resonance imaging examinations from 2020 to 2023. Kaplan–Meier curve analysis, Cox proportional hazard model, time‐dependent receiver operating characteristic (ROC) curve and restricted cubic spline (RCS) were used to evaluate the relationship between ALI and long‐term prognosis of patients with HF in Study 1. Logistic regression analysis was used to evaluate the correlation between ALI and left ventricular reverse remodelling, and RCS was used to determine any dose–response relationship. Spearman correlation was used to evaluate the relationship between ALI and indicators of cardiac structural changes. Results Study 1 found that the average age of the patients was 68 years [inter‐quartile range (IQR) 58–76], the proportion of males was 54.3%, and there were 699 all‐cause mortality and 293 cardiovascular mortality cases. After adjusted by multivariable Cox regression analysis, elevated ALI levels were significantly associated with increased risks of all‐cause [hazard ratio (HR) = 0.58, 95% confidence interval (CI) = 0.42–0.79, P

article

English

Wiley, 2025.

advanced lung cancer inflammation index, all‐cause mortality, cardiac structure, cardiovascular mortality, cohort study, heart failure, Diseases of the circulatory (Cardiovascular) system, RC666-701