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Posttranslational control of lipogenesis in the tumor microenvironment

Yahui Zhu, Xingrong Lin, Xiaojun Zhou, Edward V. Prochownik, Fubing Wang, Youjun Li

Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-18 (2022)

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Bibliographic Details
Title Posttranslational control of lipogenesis in the tumor microenvironment
Authors Yahui Zhu, Xingrong Lin, Xiaojun Zhou, Edward V. Prochownik, Fubing Wang, Youjun Li
Publication Year
2022
Source
Journal of Hematology & Oncology, Vol 15, Iss 1, Pp 1-18 (2022)
Description
Abstract Metabolic reprogramming of cancer cells within the tumor microenvironment typically occurs in response to increased nutritional, translation and proliferative demands. Altered lipid metabolism is a marker of tumor progression that is frequently observed in aggressive tumors with poor prognosis. Underlying these abnormal metabolic behaviors are posttranslational modifications (PTMs) of lipid metabolism-related enzymes and other factors that can impact their activity and/or subcellular localization. This review focuses on the roles of these PTMs and specifically on how they permit the re-wiring of cancer lipid metabolism, particularly within the context of the tumor microenvironment.
Document Type
article
Language
English
Publisher Information
BMC, 2022.
Subject Terms
Posttranslational modification, Cancer, Tumor microenvironment, Lipid metabolism reprogramming, Diseases of the blood and blood-forming organs, RC633-647.5, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
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