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Academic Journal
The pharmacoepidemiology of potential drug-drug interactions in patients with psychiatric disorders
O. O. Kirilochev, A. R. Umerova
Качественная клиническая практика, Vol 0, Iss 3, Pp 85-92 (2020)
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| Title | The pharmacoepidemiology of potential drug-drug interactions in patients with psychiatric disorders |
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| Authors | O. O. Kirilochev, A. R. Umerova |
| Publication Year |
2020
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| Source |
Качественная клиническая практика, Vol 0, Iss 3, Pp 85-92 (2020)
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| Description |
Actuality. Drug safety issues in patients with psychiatric disorders are relevant due to specifics of clinical pharmacology of the medicinal products used, possible treatment-resistance of mental illnesses and concomitant use of multiple antipsychotic drugs. One of the aspects of treatment safety is a prediction of drug-drug interactions.The aim of the study was to analyze potential drug-drug interactions in patients with psychiatric disorders.Materials and methods. The study enrolled 500 patients with psychiatric disorders in two age-related groups. Drug therapy was analyzed to reveal potential cases of drug-drug interactions.Results. A total of 1 031 cases of the use of drug combinations leading to drug-drug interactions of various clinical significance were revealed in 72.4 % of patients. There were significant differences between two age-related groups in respect of the specifics of medications use and clinical significance of drug combinations.Conclusion. Prediction of drug-drug interactions is likely to ensure improved drug safety in patients with psychiatric disorders.
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| Document Type |
article
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| Language |
Russian
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| Publisher Information |
Izdatelstvo OKI, 2020.
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| Subject Terms | |
