[Objective]: To evaluate the diagnostic value of sonoelastography to distinguish endometrial cancer from benign endometrial lesions. [Methods]: A cross-sectional study was conducted and included 31 subjects with abnormal uterine bleeding who required endometrial sampling. Sonoelastography assessment was done qualitatively and quantitatively using Tsukuba elasticity score and strain ratio, respectively. Results were compared between those with endometrial cancer and those with benign endometrial lesions (hyperplasia and polyp) using Kruskal-Wallis test and Mann-Whitney U test. Diagnostic accuracies of Tsukuba elasticity score and strain ratio in differentiating endometrial cancer from benign endometrial lesions were determined with cut-off values derived from ROC analysis. [Discussion]: Both the Tsukuba elasticity score and strain ratio value were significantly higher among patients with endometrial cancer (n = 15; mean age: 55.07 ± 8.53 years) compared to those with benign endometrial lesions (n = 16; mean age: 41.63 ± 8.02 years) (P