Objective To investigate the effects of Chinese herbal medicine ointment and sequential six-character formula on pulmonary infection control
Objective To investigate the effects of Chinese herbal medicine ointment and sequential six-character formula on pulmonary infection control (PIC) window opening time, exercise endurance and pulmonary function rehabilitation in patients with acute exacerbation of chronic obstructive pulmonary disease(COPD). Methods A total of 74 patients with acute exacerbation of COPD who were hospitalized from January 2022 to October 2024 were selected as the study objects by convenient sampling method. Interval randomization method was used to divide 37 cases into the experimental group and 37 cases into the control group. Both groups were given conventional Western medicine treatment and nursing care. The control group was given six-character formula after the PIC window was opened, and the experimental group was given six-character formula, followed by the sequential use of Chinese herbal medicine ointment after the PIC window was opened. The changes of PIC window opening time, Traditional Chinese Medicine syndrome score, dyspnea degree (mMRC), lung function and 6-minute walking distance (6MWD) were compared between the two groups. Results The opening time of PIC window in experimental group was earlier than that in control group (P＜0. 05). After 2 weeks of intervention, TCM syndrome score and mMRC in 2 groups were significantly improved compared with before intervention, and the experimental group was better than the control group (P＜0. 05). After 6 weeks of intervention, the lung function of 2 groups was improved compared with that when the PIC window was opened (P＜0. 05), but there was no significant difference between groups (P＞0. 05). After 6 weeks of intervention, 6MWD in the two groups was better than that in the control group when the PIC window was opened (P＜0. 05). Conclusion The clinical efficacy of Chinese herbal medicine ointment and sequential six-character formula in the treatment of patients with acute exacerbation of COPD is better than that of single use of six-character formula, which can reduce the time required for PIC window opening, alleviate dyspnea symptoms, increase exercise endurance, improve lung function, and no adverse reactions. (目的 探讨中药膏摩序贯“六字诀”对慢性阻塞性肺疾病急性加重期患者肺部感染控制(PIC)窗开启所需时间、运动耐力及肺功能康复的影响。方法 采用便利抽样法, 选取2022年1月—2024年10月在北京中医药大学东方医院呼吸热病科住院治疗的74例慢性阻塞性肺疾病急性加重期患者为研究对象。采用区间随机化方法分为试验组37例和对照组37例。两组均给予常规西医治疗护理, 对照组待PIC窗开启后给予“六字诀”, 试验组给予中药膏摩序贯“六字诀”, 均干预6周。比较两组患者PIC窗开启所需时间、中医证候积分、呼吸困难程度(mMRC)、肺功能、6分钟步行距离(6MWD)的变化。结果 试验组PIC窗开启所需时间早于对照组(P＜0. 05); 两组干预2周后中医证候积分、mMRC较干预前均有明显改善, 且试验组优于对照组(P＜0. 05); 两组干预6周后肺功能较PIC窗开启时改善(P＜0. 05), 但组间差异无统计学意义(P＞0. 05); 两组干预6周后6MWD较PIC窗开启时改善, 且试验组优于对照组(P＜0. 05)。结论 中药膏摩序贯“六字诀”治疗慢性阻塞性肺疾病急性加重期患者临床疗效优于单纯“六字诀”治疗, 可减少PIC窗开启所需时间, 减轻呼吸困难症状, 增加运动耐力, 改善肺功能, 且无不良反应。)
