Sepsis, a life-threatening dysregulated immune response to infection, necessitates reliable biomarkers for early risk stratification and prognosis. Sepsis occurs when bacteria that cause an infection the body's overwhelming inflammatory reaction to an infection leads to extensive tissue injury, organ dysfunction, and can be deadly if not promptly addressed. This study investigates the role of Systemic immune-inflammation index (SII), Systemic inflammatory response index (SIRI) and Aggregate Index of Systemic Inflammation (AISI) score in patients with sepsis. This retrospective study included 127 patients diagnosed with sepsis between November 2023 and March 2024. Neutrophil, lymphocyte and platelet levels statistically significant differences were observed in between the groups (p [Med-Science 2025; 14(1.000): 6-9]