преждевременный разрыв плодных оболочек (прпо), преждевременные роды (пр), антитела, бензо[a]пирен, эстрадиол, прогестерон, premature rupture of membranes, preterm labor, antibodies, benzo[a]pyrene, estradiol, progesterone, Medicine (General), R5-920

Aim. To determine the role of antibodies to estradiol (anti-Es), progesterone (anti-Pg), and benzo[a]pyrene (anti-Bp) in premature rupture of membranes (PROM). Materials and Methods. We recruited 68 women with PROM at 22+0-36+6 weeks and 81 women with a healthy pregnancy, with the further collection of venous blood at 22+0-36+6 weeks following measurement of anti-Es, anti-Pg, and anti-Bp IgA and IgG using enzyme-linked immunosorbent assay. Results. We detected the elevated levels of anti-Es, anti-Pg, and anti-Bp as well as increased IgA Bp/Pg, IgA Es/Pg, and IgG Bp/Pg ratios in women with PROM in 22+0-36+6 weeks compared to those without. Conclusions. Measurement of antibodies to estradiol, progesterone, and benzo[a]pyrene may be useful to predict PROM.