отравление, нарушение ритма и проводимости, сердечные гликозиды, трициклические антидепрессанты, фосфоорганические инсектициды, Medicine

Work is devoted to the most difficult poisoning with complications in the form of rhythm and conduction disorders. 128 patients with acute poisoning with cardiotoxic substances, admitted to the toxicological center, were investigated. The first group included 52 patients who took medications suppressing the automaticity and conduction of the heart and leading to the most severe disturbances of rhythm and conduction: cardiac glycosides - 8, b-adrenoblocators - 8, verapamil - 6 and clonidine - 30 patients. The second group of 23 patients with the poisoning by the water and spirit tincture of hellebore providing a reflex effect on the chemoreceptors and cause more light violations of rhythm and conduction disturbances. The third group of 25 patients with trycyclyc antidepressants (TADs) having a cholynolytyc effect and inducing stimulating of automatism and excitability of the heart. The fourth group (28 patients) included phosphororganic insecticides (PHOI) with antycholynesteraze action suppressing the heart automatism and conductivity. Violations of rhythm and conductivity of the heart in case of poisoning with cardiotoxic substances often manifested in the form of bradyarrhythmias. The exception is a tricyclic antidepressant poisoning. In somatogenic phase of acute poisoning with cardiotoxic substances with a favorable outcome rhythm and cardiac conduction disturbances disappeared, indicating their functional character.