Loading…
Academic Journal
Obesity Duration, Severity, and Distribution Trajectories and Cardiovascular Disease Risk in the Atherosclerosis Risk in Communities Study
Laura M. Raffield, Annie Green Howard, Misa Graff, Dan‐Yu Lin, Susan Cheng, Ellen Demerath, Chiadi Ndumele, Priya Palta, Casey M. Rebholz, Sara Seidelmann, Bing Yu, Penny Gordon‐Larsen, Kari E. North, Christy L. Avery
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 24 (2021)
Saved in:
| Title | Obesity Duration, Severity, and Distribution Trajectories and Cardiovascular Disease Risk in the Atherosclerosis Risk in Communities Study |
|---|---|
| Authors | Laura M. Raffield, Annie Green Howard, Misa Graff, Dan‐Yu Lin, Susan Cheng, Ellen Demerath, Chiadi Ndumele, Priya Palta, Casey M. Rebholz, Sara Seidelmann, Bing Yu, Penny Gordon‐Larsen, Kari E. North, Christy L. Avery |
| Publication Year |
2021
|
| Source |
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 24 (2021)
|
| Description |
Background Research examining the role of obesity in cardiovascular disease (CVD) often fails to adequately consider heterogeneity in obesity severity, distribution, and duration. Methods and Results We here use multivariate latent class mixed models in the biracial Atherosclerosis Risk in Communities study (N=14 514; mean age=54 years; 55% female) to associate obesity subclasses (derived from body mass index, waist circumference, self‐reported weight at age 25, tricep skinfold, and calf circumference across up to four triennial visits) with total mortality, incident CVD, and CVD risk factors. We identified four obesity subclasses, summarized by their body mass index and waist circumference slope as decline (4.1%), stable/slow decline (67.8%), moderate increase (24.6%), and rapid increase (3.6%) subclasses. Compared with participants in the stable/slow decline subclass, the decline subclass was associated with elevated mortality (hazard ratio [HR] 1.45, 95% CI 1.31, 1.60, P
|
| Document Type |
article
|
| Language |
English
|
| Publisher Information |
Wiley, 2021.
|
| Subject Terms | |
