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Pan-immune-inflammation value as a novel prognostic biomarker for digestive system cancers: a meta-analysis

Dongli Yu, Jingting Liu, Chunyan Meng, Baoqing Liu, Jianhua Liao

World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-12 (2024)

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Bibliographic Details
Title Pan-immune-inflammation value as a novel prognostic biomarker for digestive system cancers: a meta-analysis
Authors Dongli Yu, Jingting Liu, Chunyan Meng, Baoqing Liu, Jianhua Liao
Publication Year
2024
Source
World Journal of Surgical Oncology, Vol 22, Iss 1, Pp 1-12 (2024)
Description
Abstract Background Digestive system cancers pose a significant global health challenge with high incidence and mortality rates. Inflammation is a key factor in cancer progression, necessitating reliable prognostic indicators. The pan-immune-inflammation value (PIV), as a new biomarker of immune-inflammatory response, has emerged as a potential prognostic biomarker for cancers. Methods We performed a meta-analysis to evaluate the prognostic significance of PIV in digestive system cancers. Our search, up to June 2024, included 20 studies from 19 articles with 5037 patients. We extracted and analyzed data on PIV levels and assessed hazard ratios (HRs) for overall survival (OS), progression-free survival (PFS), disease-free survival (DFS), recurrence-free survival (RFS), and cancer-specific survival (CSS) using STATA 14.0. Results Our analysis found that high PIV levels were significantly associated with poor prognosis in patients with digestive system cancers. Specifically, high PIV was linked to shorter OS (HR = 2.039, P
Document Type
article
Language
English
Publisher Information
BMC, 2024.
Subject Terms
Pan-immune-inflammation value, Cancer, Meta-analysis, Prognosis, Biomarker, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
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