Tube-in-tube reactor, Gas-liquid mass transfer rate, Biosynthetic process, Gas-liquid reaction, Chemical engineering, TP155-156, Biochemistry, QD415-436

Recently, the continuous tube-in-tube reactor based on the Teflon AF membrane is emerging as a powerful toolkit for accelerating gas-liquid mass transfer and reaction rate. Because of its large gas-liquid interfacial area and short mass transfer distance, the reactor can allow a fast gas-liquid mass transfer without direct contact between gas and liquid phases, offering an efficient and safe platform for implementing gas-liquid reaction and rapid determination of gas-liquid parameters. In this review, a detailed description and construction method of this reactor are provided. Then, the recent advancements of the tube-in-tube reactor in fundamental studies and practical applications in gas-involved chemical reactions and biosynthetic processes are discussed. Finally, a perspective on future potential applications of such flow reactors is provided.