This literature review examined publications on cognitive reserve and multiple sclerosis cognitive function. Educational attainment proxied cognitive reserve. Google Scholar and KoBSON were used for the literature review. Twelve publications were examined. Cognitive reserve improves multiple sclerosis patients’ cognitive functions, according to selected literature. Higher education, as a measure of cognitive reserve, protects the population under investigation against cognitive decline and disability. Cognitive performance is also linked to education quality, cognitive enrichment, and years of education. Regular exercise, reading, and hard work can help low-educated people protect their cognitive reserve. As more research demonstrates that cognitively stimulating activities outside of formal education can improve cognitive function in people with multiple sclerosis, the reviewed studies underscore the need for additional research into parameters influencing cognitive reserve.