atherosclerosis, novel inflammatory biomarkers, systemic immune-inflammation index (sii), systemic inflammation response index (siri), aggregate index of systemic inflammation (aisi), Diseases of the circulatory (Cardiovascular) system, RC666-701

Aim. To compare the levels of novel biomarkers of systemic inflammation in pati­ents with and without atherosclerosis, as well as between groups of patients with atherosclerosis of different severity.Material and methods. Patients with suspected coronary artery disease after selective coronary angiography were included. The analysis included 901 patients with mean age of 61±10 years (men, 60% (n=549)). The patients were divided into two following groups: with and without atherosclerosis. The Propensity Score Matching method was used to adjust for baseline clinical differences.Results. In the group with atherosclerosis, the values of the systemic inflam­mation response index (SIRI), systemic immune-inflammation index (SII) and ag­gregate index of systemic inflammation (AISI) were significantly higher than in patients without atherosclerosis: 0,906 (0,632; 1,36) vs 0,745 (0,519; 1,02), p1,05, area under the curve (AUC) confidence interval (CI) — 0,615 (0,571-0,658), p368, AUC CI — 0,572 (0,528-0,616), p=0,004, sensitivity — 72,1%, specificity — 43,4%; for AISI >248, AUC CI — 0,604 (0,560-0,647), p1,05, for SII >368, for AISI >248.