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Academic Journal
Activity of blood kallikrein-kinin and renin-angiotensin systemsin newborns with hypoxic-ishaemic encephalopathy
G. A. Soukhanova, Ye. I. Kondratyeva, T. Ye. Gunbina, V. V. Gorev, T. N. Khlynina
Бюллетень сибирской медицины, Vol 6, Iss 2, Pp 114-117 (2007)
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| Title | Activity of blood kallikrein-kinin and renin-angiotensin systemsin newborns with hypoxic-ishaemic encephalopathy |
|---|---|
| Authors | G. A. Soukhanova, Ye. I. Kondratyeva, T. Ye. Gunbina, V. V. Gorev, T. N. Khlynina |
| Publication Year |
2007
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| Source |
Бюллетень сибирской медицины, Vol 6, Iss 2, Pp 114-117 (2007)
|
| Description |
Oxygen insufficiency in newborns is associated with disturbed vascular tone, which are regulated by kallikrein-kinin (KKS) and renin-angiotensin systems (RAS).Important index of hemodynamic disturbances is the activity of kallikrein, of angiotensin-converting enzyme (ACE) and also inhibitors of proteinases: α1-proteinase inhibitor and α2-macroglobulin. In hypoxic-ischemic encephalopathy of mature newborns and children of the I, II premature degrees , blood KKS activity is increased in comparison with RAS. Decreased activity of α1-proteinase inhibitor is seen in 46% of premature infants of II degree which usually leads to chronic pathologic process. The increased activity of ACE is important for preventing hemodynamic disturbances.
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| Document Type |
article
|
| Language |
English
Russian |
| Publisher Information |
Siberian State Medical University (Tomsk), 2007.
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| Subject Terms | |
