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INDICATORS OF CHEMILUMINESCENT ACTIVITY OF NEUTROPHILIC GRANULOCYTES IN HELICOBACTER PYLORI, ASSOCIATED STOMACH CANCER
Olga Valentinovna Smirnova, Vladislav Vladimirovich Tsukanov, Alexander Alexandrovich Sinyakov, Olga Leonidovna Moskalenko, Nina Georgievna Elmanova, Elizaveta Sergeevna Ovcharenko, Irina Eduardovna Kasparova
Siberian Journal of Life Sciences and Agriculture, Vol 11, Iss 2, Pp 139-154 (2019)
Sparad:
| Titel | INDICATORS OF CHEMILUMINESCENT ACTIVITY OF NEUTROPHILIC GRANULOCYTES IN HELICOBACTER PYLORI, ASSOCIATED STOMACH CANCER |
|---|---|
| Författarna | Olga Valentinovna Smirnova, Vladislav Vladimirovich Tsukanov, Alexander Alexandrovich Sinyakov, Olga Leonidovna Moskalenko, Nina Georgievna Elmanova, Elizaveta Sergeevna Ovcharenko, Irina Eduardovna Kasparova |
| Utgivningsår |
2019
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| Källa |
Siberian Journal of Life Sciences and Agriculture, Vol 11, Iss 2, Pp 139-154 (2019)
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| Beskrivning |
One of the leading and unresolved problems in medicine is gastric cancer. The risk of developing RJ in H. pylori-infected patients is 2–4 times higher than in uninfected patients. The role of the cells of the immune system in the transformation of chronic atrophic gastritis in the Russian pancreas is undeniable, while the first cells that respond to a foreign antigen are neutrophilic granulocytes (NG). The aim of our work was to study the chemiluminescent activity of neutrophilic granulocytes in Helicobacter pylori, associated gastric cancer. A survey of 50 patients with chronic atrophic gastritis (CAH) and 50 patients with gastric cancer (RG) was performed. The control group consisted of 85 healthy donors. Evaluation of spontaneous and induced chemiluminescence (CL) was carried out for 90 minutes on a 36-channel chemiluminescent analyzer “CL 3606” (Russia). The following indicators were determined: the time the curve reached the maximum CL intensity, the maximum value of the CL intensity, the area under the CL curve. As an amplifier used luminol. The respiratory burst inducer was the opsonized zymosan. The enhancement of CL induced by opsonized zymosan was evaluated by the ratio of the area induced to the area of spontaneous CL and indicated by the activation index. Statistical data processing was carried out using Statistica for Windows 8.0 application software packages. The critical level of significance in testing statistical hypotheses was taken to be p
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| Dokumenttyp |
article
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| Språk |
English
Russian |
| Information om utgivare |
Science and Innovation Center Publishing House, 2019.
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| Ämnestermer | |
