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Academic Journal
Study of the mechanisms cardioprotektive effect of 3-(2,2,2- trimethylhydrazinium) propionate
L. M. Danilenko, M. V. Pokrovsky, M. V. Korokin, O. S. Gudyrev
Кубанский научный медицинский вестник, Iss 1, Pp 24-26 (2016)
Sparad:
| Titel | Study of the mechanisms cardioprotektive effect of 3-(2,2,2- trimethylhydrazinium) propionate |
|---|---|
| Författarna | L. M. Danilenko, M. V. Pokrovsky, M. V. Korokin, O. S. Gudyrev |
| Utgivningsår |
2016
|
| Källa |
Кубанский научный медицинский вестник, Iss 1, Pp 24-26 (2016)
|
| Beskrivning |
The work evaluated the influence of 3-(2,2,2-trimethylhydrazinium) propionate per square necrotic myocardium of the left ventricle and the level troponina I serum during acute coronary occlusion (60 minutes) followed by reperfusion (90 min) in anesthetized rabbits. It is shown that distant and pharmacological preconditioning 3 (2,2,2-trimethylhydrazinium) propionate reduce nekrooza zone 3 and 1.5 times, respectively. Found participation ATP dependent potassium channels (KATF channels) of endothelial and inducible NO-synthase in the implementation of the cytoprotective effect of distant preconditioning and 3-(2,2,2-trimethylhydrazinium) propionate, indicating that the implementation of the mechanism of pharmacological preconditioning in his kardioprotektvnom action.
|
| Dokumenttyp |
article
|
| Språk |
Russian
|
| Information om utgivare |
Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”, 2016.
|
| Ämnestermer | |
