Stress hyperglycemia ratio, Ischemic heart disease, Mortality, MIMIC-III database, Diseases of the circulatory (Cardiovascular) system, RC666-701

Abstract Background The stress hyperglycaemia ratio (SHR), a quantitative indicator of hyperglycaemia in stress, has been shown to correlate with poor disease prognosis. However, the relationship between SHR and short-term prognosis in critically ill patients with ischemic heart disease (IHD) remains unclear. Methods This retrospective study analyzed data of 2559 critically ill patients with IHD from the Medical Information Mart for Intensive Care III database. Endpoints were in-hospital mortality and intensive care unit (ICU) mortality. Kaplan-Meier survival curves, Cox proportional hazards models, restricted cubic spline, subgroup analysis, and receiver operating characteristic curves were used to explore the association between SHR and mortality in critically ill patients with IHD. Results A total of 99 (3.87%) in-hospital deaths and 62 (2.42%) ICU deaths were recorded. In multivariate Cox proportional hazards models, higher SHR was independently associated with in-hospital mortality (hazard ratio (HR): 1.93 [95% confidence interval (CI): 1.42–2.61], P-value