Loading…
Academic Journal
Targeting CD22 for B-cell hematologic malignancies
Jia Xu, Wenjing Luo, Chenggong Li, Heng Mei
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-14 (2023)
Saved in:
| Title | Targeting CD22 for B-cell hematologic malignancies |
|---|---|
| Authors | Jia Xu, Wenjing Luo, Chenggong Li, Heng Mei |
| Publication Year |
2023
|
| Source |
Experimental Hematology & Oncology, Vol 12, Iss 1, Pp 1-14 (2023)
|
| Description |
Abstract CD19-targeted chimeric receptor antigen (CAR)-T cell therapy has shown remarkable clinical efficacy in the treatment of relapsed or refractory (R/R) B-cell malignancies. However, 30%–60% of patients eventually relapsed, with the CD19-negative relapse being an important hurdle to sustained remission. CD22 expression is independent of CD19 expression in malignant B cells. Consequently, CD22 is a potential alternative target for CD19 CAR-T cell-resistant patients. CD22-targeted therapies, mainly including the antibody–drug conjugates (ADCs) and CAR-T cells, have come into wide clinical use with acceptable toxicities and promising efficacy. In this review, we explore the molecular and physiological characteristics of CD22, development of CD22 ADCs and CAR-T cells, and the available clinical data on CD22 ADCs and CAR-T cell therapies. Furthermore, we propose some perspectives for overcoming tumor escape and enhancing the efficacy of CD22-targeted therapies.
|
| Document Type |
article
|
| Language |
English
|
| Publisher Information |
BMC, 2023.
|
| Subject Terms | |
