метапневмовирус птиц, клеточный и гуморальный иммунитет, патогенез, avian metapneumovirus, cell-mediated and antibody-mediated immunity, pathogenesis, Veterinary medicine, SF600-1100

Experimental infection of 7-day-old chicks with the isolate of avian metapneumovirus Subtype В induced mild signs of respiratory infection and swelled infraorbital sinuses in 5-15 days post infection. Lesions in tissues of trachea, nasal passages and primary lymphoid organs were reported. Using real-time RT-PCR avian metapneumovirus genome was detected in the upper part of the respiratory tract, infraorbital sinuses and Harderian gland within 2-12 days post infection. The immune response was characterized by formation of humoral and local antibodies in 7-21 days post infection. In 3 days post infection increased percentage of CD8a+ T-cell subpopulation was reported in blood and spleen of the infected chicks.