Medical and Health Sciences, Basic Medicine, Epidemiology, Medicin och hälsovetenskap, Medicinska och farmaceutiska grundvetenskaper, Epidemiologi, Health Sciences, Health Care Service and Management, Health Policy and Services and Health Economy, Hälsovetenskap, Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi

Background Early initiation of breastfeeding, defined as breastfeeding within one hour of birth, halves the risk of neonatal mortality, establishing it as a crucial outcome component in various interventions implemented across South Asian countries. However, the overall effect of these interventions remain unexamined. Therefore, this study seeks to address this knowledge gap by evaluating the overall effect of these interventions on maternal early initiation of breastfeeding practice. Methods A systematic literature search was performed to identify randomised controlled trials conducted in South Asia focusing on early initiation of breastfeeding as an outcome variable. The interventions identified were categorized into behavioral, mobile health (mHealth), health system strengthening, and nutritional interventions. Random effects meta-analysis was conducted to estimate the pooled effect of interventions and effectiveness by intervention categories. Heterogeneity was explored by sub-group and meta-regression analyses. The risk of bias and strength of evidence were assessed by Cochrane’s RoB2 assessment tool and GRADE criteria, respectively. Results We included 22 articles published, representing 19 unique interventions, from a pool of 2,524 screened records for review and narrative synthesis. Among these, 19 articles were eligible for meta-analysis. The pooled relative risk (RR) of early initiation of breastfeeding among mothers in the intervention groups, as compared to their counterparts, was 1.55 (95% CI: 1.24, 1.95; I2 = 99.56; p < 0.001). Interventions targeted health system strengthening represented stronger effect than other types of interventions. The overall strength of evidence was moderate. Conclusion The overall intervention effect appeared efficacious in improving maternal early initiation of breastfeeding practice in South Asia, providing valuable insights for policymakers to develop contextually feasible strategies.