Sökresultat - "LYSOSOMES"

Engineered cell membrane vesicles loaded with lysosomophilic drug for acute myeloid leukemia therapy via organ-cell-organelle cascade-targeting.

Jin F; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Wei X; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Liu Y; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Tang L; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Ren J; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Yang J; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Lin C; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Hu J; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Sun M; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Li G; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Yuan Z; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Zhao W; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China., Wang X; Jiangxi Province Key Laboratory of Immunology and Inflammation, Jiangxi Provincial Clinical Research Center for Laboratory Medicine, Department of Clinical Laboratory, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, 330006, Jiangxi, China., Yang Z; Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China., Zhang L; Key Laboratory of Laboratory Medical Diagnostics Designated by the Ministry of Education, College of Laboratory Medicine, Chongqing Medical University, Chongqing, 400016, China. Electronic address: lingzhang@cqmu.edu.cn.

Journal Article , 2025

Recovery of Lysosomal Acidification and Autophagy Flux by Attapulgite Nanorods: Therapeutic Potential for Lysosomal Disorders.

Hao Y; School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China., Fan X; School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China., Huang X; School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China., Li Z; School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China., Jing Z; School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China., Zhang G; School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China., Xu Y; School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China., Zhang N; School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China., Wei P; School of Pharmacy, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, China.

Journal Article , 2025

Induced mitochondrial deficit by NDUFS3 transient silencing reduces RAB7 expression and causes lysosomal dysfunction in pancreatic cancer cells.

Girolimetti G; Department of Experimental Medicine, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy., Gagliardi S; Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy., Cordella P; Department of Experimental Medicine, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy., Bramato G; Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy., Di Corato R; Institute for Microelectronics and Microsystems (IMM), CNR, Via Provinciale Lecce-Monteroni, Lecce, 73100, Italy.; Center for Biomolecular Nanotechnologies, Istituto Italiano di Tecnologia, Arnesano, 73010, Italy., Romano R; Department of Experimental Medicine, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy., Guerra F; Department of Biological and Environmental Sciences and Technologies, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy., Bucci C; Department of Experimental Medicine, University of Salento, Via Provinciale Lecce-Monteroni n. 165, Lecce, 73100, Italy. cecilia.bucci@unisalento.it.

Journal Article , 2025

Deciphering tuberculosis: lysosome-centric insights into pathogenesis and therapies.

Bao C; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Respiratory and Critical Care Medicine, The Second Clinical Medical School of Nanjing Medical University, Nanjing, Jiangsu, China., Zhang Y; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Respiratory and Critical Care Medicine, The Second Clinical Medical School of Nanjing Medical University, Nanjing, Jiangsu, China., Feng J; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Respiratory and Critical Care Medicine, The Second Clinical Medical School of Nanjing Medical University, Nanjing, Jiangsu, China., Hong X; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Respiratory and Critical Care Medicine, The Second Clinical Medical School of Nanjing Medical University, Nanjing, Jiangsu, China., Gao N; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.; Department of Respiratory and Critical Care Medicine, The Second Clinical Medical School of Nanjing Medical University, Nanjing, Jiangsu, China., Feng G; Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Journal Article; Review , 2025

Linear ubiquitination at damaged lysosomes induces local NFKB activation and controls cell survival.

Zein L; Institute for Experimental Pediatric Hematology and Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany., Dietrich M; Institute for Experimental Pediatric Hematology and Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany., Balta D; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Bader V; Department of Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany., Scheuer C; Institute for Experimental Pediatric Hematology and Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany., Zellner S; Munich Cluster for Systems Neurology (SyNergy), Faculty of Medicine, LMU Munich, München, Germany., Weinelt N; Institute for Experimental Pediatric Hematology and Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany., Vandrey J; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Mari MC; Department of Biomedicine, Aarhus University, Aarhus, Denmark., Behrends C; Munich Cluster for Systems Neurology (SyNergy), Faculty of Medicine, LMU Munich, München, Germany., Zunke F; Department of Molecular Neurology, University Hospital Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany., Winklhofer KF; Department of Molecular Cell Biology, Institute of Biochemistry and Pathobiochemistry, Ruhr University Bochum, Bochum, Germany.; Cluster of Excellence RESOLV, Bochum, Germany., Van Wijk SJL; Institute for Experimental Pediatric Hematology and Oncology, Goethe University Frankfurt, Frankfurt am Main, Germany.; German Cancer Consortium (DKTK) partner site Frankfurt/Mainz and German Cancer Research Center (DKFZ), Heidelberg, Germany.; University Cancer Centre Frankfurt (UCT), University Hospital Frankfurt, Goethe-University Frankfurt, Frankfurt, Germany.

Journal Article , 2025

Lysosomes and LAMPs as Autophagy Drivers of Drug Resistance in Colorectal Cancer.

Ivanova T; Department of Medical Biology, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria.; Research Division of Molecular and Regenerative Medicine, Research Institute at Medical University-Plovdiv, 4000 Plovdiv, Bulgaria., Sbirkov Y; Department of Medical Biology, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria.; Research Division of Molecular and Regenerative Medicine, Research Institute at Medical University-Plovdiv, 4000 Plovdiv, Bulgaria., Kazakova M; Department of Medical Biology, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria.; Research Division of Molecular and Regenerative Medicine, Research Institute at Medical University-Plovdiv, 4000 Plovdiv, Bulgaria., Sarafian V; Department of Medical Biology, Medical University-Plovdiv, 4000 Plovdiv, Bulgaria.; Research Division of Molecular and Regenerative Medicine, Research Institute at Medical University-Plovdiv, 4000 Plovdiv, Bulgaria.

Journal Article; Review; Research Support, Non-U.S. Gov't , 2025

Oxidative Stress, Lysosomal Permeability, and Mitochondrial-Derived Vesicles Induced in NL-20 Human Bronchial Cells Exposed to Benzo[ghi]Perylene.

Lizardo LP; Laboratorio de Investigación en Patología Experimental, Hospital Infantil de México Federico Gómez, Avenida Dr. Márquez 162, Colonia Doctores, Cuauhtémoc, 06720 Ciudad de México, Mexico. Electronic address: angel.lopez.pe@usb.edu.mx., Elisa RB; Laboratorio de Investigación en Patología Experimental, Hospital Infantil de México Federico Gómez, Avenida Dr. Márquez 162, Colonia Doctores, Cuauhtémoc, 06720 Ciudad de México, Mexico; Posgrado en Ciencias Biológicas, Unidad de Posgrado, Edificio D, 1° Piso, Circuito de Posgrados, Ciudad Universitaria, Coyoacán, C.P, 04510 CDMX, Mexico. Electronic address: andrearb@ciencias.unam.mx., Tania XR; Laboratorio de Investigación en Patología Experimental, Hospital Infantil de México Federico Gómez, Avenida Dr. Márquez 162, Colonia Doctores, Cuauhtémoc, 06720 Ciudad de México, Mexico., Ulises TF; Laboratorio de Investigación en Patología Experimental, Hospital Infantil de México Federico Gómez, Avenida Dr. Márquez 162, Colonia Doctores, Cuauhtémoc, 06720 Ciudad de México, Mexico., Brandon LQ; Laboratorio de Investigación en Patología Experimental, Hospital Infantil de México Federico Gómez, Avenida Dr. Márquez 162, Colonia Doctores, Cuauhtémoc, 06720 Ciudad de México, Mexico. Electronic address: brandon.licea.qu@usb.edu.mx., Regina MQ; Laboratorio de Investigación en Patología Experimental, Hospital Infantil de México Federico Gómez, Avenida Dr. Márquez 162, Colonia Doctores, Cuauhtémoc, 06720 Ciudad de México, Mexico. Electronic address: regina.monrroy.qu@usb.edu.mx., Carlos CJ; Laboratorio de Investigación en Neurociencias, Hospital Infantil de México Federico Gómez, Avenida Dr. Márquez 162, Colonia Doctores, Cuauhtémoc, 06720 Ciudad de México, Mexico., Montserrat ZO; Laboratorio de Investigación en Patología Experimental, Hospital Infantil de México Federico Gómez, Avenida Dr. Márquez 162, Colonia Doctores, Cuauhtémoc, 06720 Ciudad de México, Mexico., Francisco AH; Laboratorio de Investigación en Patología Experimental, Hospital Infantil de México Federico Gómez, Avenida Dr. Márquez 162, Colonia Doctores, Cuauhtémoc, 06720 Ciudad de México, Mexico. Electronic address: farenashuertero@yahoo.com.mx.

Journal Article , 2025

Exposure to polystyrene nanoplastics induces lysosomal enlargement and lipid droplet accumulation in KGN human ovarian granulosa cells.

Zhang Y; Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin, 150081, China.; Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, H3G 1Y6, Canada., Hales BF; Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, H3G 1Y6, Canada., Robaire B; Department of Pharmacology and Therapeutics, McGill University, 3655 Promenade Sir William Osler, Montreal, QC, H3G 1Y6, Canada. bernard.robaire@mcgill.ca.; Department of Obstetrics and Gynecology, McGill University, Montreal, QC, H3G 1Y6, Canada. bernard.robaire@mcgill.ca.

Journal Article , 2025

Polystyrene nanoplastics trigger pyroptosis in dopaminergic neurons through TSC2/TFEB-mediated disruption of autophagosome-lysosome fusion in Parkinson's disease.

Liang X; Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Province, Southern Medical University, Guangzhou, 510080, China.; Guangzhou Key Laboratory of Diagnosis and Treatment for Neurodegenerative Diseases, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou, 510080, China., Zeng Y; College of Natural Resources and Environment, Key Laboratory of Arable Land Conservation (South China), MOA, Guangdong Provincial Key Laboratory of Agricultural & Rural Pollution Abatement and Environmental Safety, South China Agricultural University, Guangzhou, 510642, Guangdong, China., Zhang P; Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Province, Southern Medical University, Guangzhou, 510080, China.; Guangzhou Key Laboratory of Diagnosis and Treatment for Neurodegenerative Diseases, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou, 510080, China., Zhu B; Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Province, Southern Medical University, Guangzhou, 510080, China.; Guangzhou Key Laboratory of Diagnosis and Treatment for Neurodegenerative Diseases, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou, 510080, China., Feng J; Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Province, Southern Medical University, Guangzhou, 510080, China.; Guangzhou Key Laboratory of Diagnosis and Treatment for Neurodegenerative Diseases, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou, 510080, China.; School of Medicine, South China University of Technology, Guangzhou, 510006, China., Deng T; Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Province, Southern Medical University, Guangzhou, 510080, China.; Guangzhou Key Laboratory of Diagnosis and Treatment for Neurodegenerative Diseases, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou, 510080, China.; School of Medicine, South China University of Technology, Guangzhou, 510006, China., Fu Z; Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Province, Southern Medical University, Guangzhou, 510080, China.; Guangzhou Key Laboratory of Diagnosis and Treatment for Neurodegenerative Diseases, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou, 510080, China., Liu C; College of Natural Resources and Environment, Key Laboratory of Arable Land Conservation (South China), MOA, Guangdong Provincial Key Laboratory of Agricultural & Rural Pollution Abatement and Environmental Safety, South China Agricultural University, Guangzhou, 510642, Guangdong, China., Chen C; College of Natural Resources and Environment, Key Laboratory of Arable Land Conservation (South China), MOA, Guangdong Provincial Key Laboratory of Agricultural & Rural Pollution Abatement and Environmental Safety, South China Agricultural University, Guangzhou, 510642, Guangdong, China. cychen@scau.edu.cn., Zhang Y; Department of Neurology, Guangdong Neuroscience Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangdong Province, Southern Medical University, Guangzhou, 510080, China. zhangyuhu@gdph.org.cn.; Guangzhou Key Laboratory of Diagnosis and Treatment for Neurodegenerative Diseases, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Guangzhou, 510080, China. zhangyuhu@gdph.org.cn.; School of Medicine, South China University of Technology, Guangzhou, 510006, China. zhangyuhu@gdph.org.cn.

Journal Article , 2025

PFOS causes lysosomes-regulated mitochondrial fission through TRPML1-VDAC1 and oligomerization of MCU/ATP5J2.

Yang W; Occupational and Environmental Health Department, Dalian Medical University, 9 West Lvshun South Road, Dalian 116044, China., Li Y; Occupational and Environmental Health Department, Dalian Medical University, 9 West Lvshun South Road, Dalian 116044, China., Feng R; Occupational and Environmental Health Department, Dalian Medical University, 9 West Lvshun South Road, Dalian 116044, China., Liang P; Occupational and Environmental Health Department, Dalian Medical University, 9 West Lvshun South Road, Dalian 116044, China., Tian K; Occupational and Environmental Health Department, Dalian Medical University, 9 West Lvshun South Road, Dalian 116044, China., Hu L; Occupational and Environmental Health Department, Dalian Medical University, 9 West Lvshun South Road, Dalian 116044, China., Wang K; Occupational and Environmental Health Department, Dalian Medical University, 9 West Lvshun South Road, Dalian 116044, China., Qiu T; Occupational and Environmental Health Department, Dalian Medical University, 9 West Lvshun South Road, Dalian 116044, China., Zhang J; Occupational and Environmental Health Department, Dalian Medical University, 9 West Lvshun South Road, Dalian 116044, China., Sun X; Occupational and Environmental Health Department, Dalian Medical University, 9 West Lvshun South Road, Dalian 116044, China., Yao X; Occupational and Environmental Health Department, Dalian Medical University, 9 West Lvshun South Road, Dalian 116044, China. Electronic address: yaoxiaofeng@dmu.edu.cn.

Journal Article , 2025

Donepezil-induced degradation of hERG potassium channel via lysosomal pathway is exacerbated by hypoxia.

Li Y; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China., Sun J; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China., Li X; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China., Yu W; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China., Ren J; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China., Wang B; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China., Han X; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China., Ma L; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China., Sun X; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China., Teng W; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China., Gu X; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China., Ding Q; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China., Li B; Department of Pharmacology, College of Pharmacy, Harbin Medical University, Harbin, China. Electronic address: libaoxin@ems.hrbmu.edu.cn.

Journal Article , 2025

Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotype.

Hellén M; Neuroscience Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Weert I; Neuroscience Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Müller SA; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany., Räsänen N; Neuroscience Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Kettunen P; Neuroscience Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Lehtonen Š; A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland., Peitz M; Institute of Reconstructive Neurobiology, University of Bonn Medical Faculty & University Hospital Bonn, Bonn, Germany.; Cell Programming Core Facility, University of Bonn Medical Faculty, Bonn, Germany., Fließbach K; Department of Old Age Psychiatry and Cognitive Disorders, University of Bonn Medical Center, Bonn, Germany.; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany., Takalo M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Koskuvi M; Neuroscience Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland., Lichtenthaler SF; German Center for Neurodegenerative Diseases (DZNE), Munich, Germany.; Neuroproteomics, School of Medicine and Health, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany., Leinonen V; Department of Neurosurgery, Kuopio University Hospital, Kuopio, Finland.; Institute of Clinical Medicine - Neurosurgery, University of Eastern Finland, Kuopio, Finland., Ramirez A; German Center for Neurodegenerative Diseases (DZNE Bonn), Bonn, Germany.; Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.; Department of Old Age Psychiatry and Cognitive Disorders, University Hospital Bonn, University of Bonn, Bonn, Germany.; Glenn Biggs Institute for Alzheimer's & Neurodegenerative Diseases, University of Texas Health Sciences Center, San Antonio, TX, USA.; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Disease (CECAD), University of Cologne, Cologne, Germany., Kärkkäinen O; Afekta Technologies Ltd, Kuopio, Finland.; School of Pharmacy, University of Eastern Finland, Kuopio, Finland., Hiltunen M; Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland., Koistinaho J; Neuroscience Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland. jari.koistinaho@helsinki.fi.; Drug Research Program, Division of Pharmacology and Pharmacotherapy, University of Helsinki, Helsinki, Finland. jari.koistinaho@helsinki.fi., Rõlova T; Neuroscience Center, Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland. taisia.rolova@helsinki.fi.

Journal Article , 2025

Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases.

Lane-Donovan C; Memory and Aging Center, Weill Institute for Neuroscience, Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Smith AW; Memory and Aging Center, Weill Institute for Neuroscience, Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Saloner R; Memory and Aging Center, Weill Institute for Neuroscience, Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Miller BL; Memory and Aging Center, Weill Institute for Neuroscience, Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Casaletto KB; Memory and Aging Center, Weill Institute for Neuroscience, Department of Neurology, University of California, San Francisco, San Francisco, California, USA., Kao AW; Memory and Aging Center, Weill Institute for Neuroscience, Department of Neurology, University of California, San Francisco, San Francisco, California, USA.; Bakar Aging Research Institute, University of California, San Francisco, San Francisco, California, USA.

Journal Article , 2025

Accumulation of microtubule-associated protein tau promotes hepatocellular carcinogenesis through inhibiting autophagosome-lysosome fusion.

Liu X; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China.; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China.; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Hao Z; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China.; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China., He H; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China.; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China., Wang X; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China.; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China., Wang W; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China., Shu X; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China.; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Sun B; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China.; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Hu Z; Department of Pathology, Renmin Hospital of Huangpi District of Jianghan University, Wuhan, 430399, China., Hu S; Liver Transplant Cancer, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China., Hou X; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China., Xiao Y; Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Education Ministry of China/Hubei Province for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China., Zhou H; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China.; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China.; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China., Liu Y; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China. yuchen.liu@jhun.edu.cn.; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China. yuchen.liu@jhun.edu.cn.; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China. yuchen.liu@jhun.edu.cn., Wang J; Hubei Key Laboratory of Cognitive and Affective Disorders, Jianghan University, Wuhan, 430056, China. wangjz@mail.hust.edu.cn.; Wuhan Institute of Biomedical Sciences, School of Medicine, Jianghan University, Wuhan, 430056, China. wangjz@mail.hust.edu.cn., Fu Z; Department of Pathology and Pathophysiology, School of Medicine, Jianghan University, 8 Sanjiaohu Road, Wuhan, 430056, China. lilyfzq@163.com.; Cancer Institute, School of Medicine, Jianghan University, Wuhan, 430056, China. lilyfzq@163.com.

Journal Article , 2025

Cholesterol-dependent Nsp5-endosomes co-trafficking to lysosomes facilitates porcine reproductive and respiratory syndrome virus replication by activating autophagy.

Dong H; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China., Pei Q; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China., Ren J; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China., Zhang Y; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China., Wei X; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China., Shen A; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China., Lu Y; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China., Zhang Z; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China., Du Y; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China., Zhuang G; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China., Zhang A; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China; Ministry of Education Key Laboratory for Animal Pathogens and Biosafety, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China. Electronic address: zhangangke1112@henau.edu.cn., Duan H; College of Veterinary Medicine, Henan Agricultural University, Zhengzhou 450046, China. Electronic address: duanhong0924@126.com.

Journal Article , 2025

Exposure of Bisphenols (BPA, BPB and BPC) in HepG2 Cells Results in Lysosomal Dysfunction and Lipid Accumulation.

Gill K; Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Bindal E; Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Garg P; Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Kumar D; Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Bhattacharyya R; Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, Chandigarh, India., Banerjee D; Experimental Medicine and Biotechnology Department, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Journal Article , 2025

Gallic acid relieved bortezomib-induced peripheral neurotoxicity by restoring Schwann cell lysosomal activity.

Liu X; Institute of Pharmacology and Toxicology, National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Wang K; Institute of Pharmacology and Toxicology, National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Zhang X; Institute of Pharmacology and Toxicology, National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Qi J; Institute of Pharmacology and Toxicology, National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Zhu D; Institute of Pharmacology and Toxicology, National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China., Wang Z; College of Medicine and Health Sciences, China Three Gorges University, Yichang 443002, China., He Z; Department of Pharmacology, College of Medicine, Jiaxing University, Jiaxing 314001, China., Yao J; Institute of Pharmacology and Toxicology, National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.; Zhejiang Conba Pharmaceutical Co., Ltd., Hangzhou 310051, China., Zhang X; Institute of Pharmacology and Toxicology, National Key Laboratory of Advanced Drug Delivery and Release Systems, Zhejiang Collaborative Innovation Center for the Brain Diseases with Integrative Medicine, Zhejiang Key Laboratory of Neuropsychopharmacology, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.; Jinhua Institute of Zhejiang University, Jinhua 321299, China., Wu J; Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, Department of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310002, China.

Journal Article , 2025

Cadmium targeting transcription factor EB to inhibit autophagy-lysosome function contributes to acute kidney injury.

Dong PF; College of Veterinary Medicine, Shandong Provincial Key Laboratory of Zoonoses, Shandong Agricultural University, 7 Panhe Street, Tai'an City, 271017, Shandong Province, China., Liu TB; New Drug Evaluation Center of Shandong Academy of Pharmaceutical Sciences, Shandong Academy of Pharmaceutical Sciences, 989 Xinluo Street, Ji'nan City, 250101, Shandong Province, China., Chen K; New Drug Evaluation Center of Shandong Academy of Pharmaceutical Sciences, Shandong Academy of Pharmaceutical Sciences, 989 Xinluo Street, Ji'nan City, 250101, Shandong Province, China., Li D; Shandong Medicine Technician College, 999 Fengtian Street, Tai'an City, 271016, Shandong Province, China., Li Y; College of Veterinary Medicine, Shandong Provincial Key Laboratory of Zoonoses, Shandong Agricultural University, 7 Panhe Street, Tai'an City, 271017, Shandong Province, China., Lian CY; College of Veterinary Medicine, Shandong Provincial Key Laboratory of Zoonoses, Shandong Agricultural University, 7 Panhe Street, Tai'an City, 271017, Shandong Province, China., Wang ZY; College of Veterinary Medicine, Shandong Provincial Key Laboratory of Zoonoses, Shandong Agricultural University, 7 Panhe Street, Tai'an City, 271017, Shandong Province, China., Wang L; College of Veterinary Medicine, Shandong Provincial Key Laboratory of Zoonoses, Shandong Agricultural University, 7 Panhe Street, Tai'an City, 271017, Shandong Province, China. Electronic address: wanglin2013@sdau.edu.cn.

Journal Article , 2025

Transcriptional repression of autophagy and lysosome biogenesis.

Kim J; Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul, Republic of Korea., Yu YS; Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul, Republic of Korea., Kim KI; Department of Biological Sciences, Sookmyung Women's University, Seoul, Republic of Korea., Baek SH; Creative Research Initiatives Center for Epigenetic Code and Diseases, School of Biological Sciences, Seoul National University, Seoul, Republic of Korea.

Journal Article , 2025

Lysosomal Fe ²⁺ influx through MCOLN1 channel prevents sustained inflammation by limiting PHDs-regulated NFKB activation in macrophages.

Wang MM; Department of Otolaryngology and Neck Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China., Wang W; Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, Jiangsu, China., Qi J; Guangdong Provincial Key Laboratory of Autophagy and Major Chronic Non-Communicable Diseases, Affiliated hospital of Guangdong Medical University, Zhanjiang, Guangdong, China.

Journal Article , 2025