Journal of gynecology obstetrics and human reproduction [J Gynecol Obstet Hum Reprod] 2025 May; Vol. 54 (5), pp. 102934. Date of Electronic Publication: 2025 Mar 06.

Publisher: Elsevier Masson SAS Country of Publication: France NLM ID: 101701588 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2468-7847 (Electronic) Linking ISSN: 24687847 NLM ISO Abbreviation: J Gynecol Obstet Hum Reprod Subsets: MEDLINE

Uterine Cervical Neoplasms*/pathology , Uterine Cervical Neoplasms*/surgery , Uterine Cervical Neoplasms*/diagnostic imaging , Positron Emission Tomography Computed Tomography*/statistics & numerical data , Positron Emission Tomography Computed Tomography*/methods , Lymph Node Excision*/methods , Lymph Node Excision*/statistics & numerical data, Humans ; Female ; Retrospective Studies ; Middle Aged ; Adult ; Reunion/epidemiology ; Aged ; Neoplasm Staging ; Lymph Nodes/pathology ; Lymph Nodes/diagnostic imaging ; Lymphatic Metastasis

Objectives: In locally advanced cervical cancer (LACC), para-aortic staging is required to determine therapeutic strategy and may be performed using PET-CT; if the scan is negative in the para-aortic region, surgical staging is optional. The aim of the study was to evaluate histological results of para-aortic lymph node dissection in patients with locally advanced cervical cancer and negative PET-CT in Reunion Island.
Materiel Et Methods: This is a bicentric retrospective study including patients from January 2014 to December 2023 at Saint-Denis and Saint-Pierre university hospitals. Patients with LACC and negative PET-CT in para-aortic region prior to lymphadenectomy were included. The primary outcome was to evaluate the rate of false negative results on PET-CT in lumbo-aortic region in patients with cervicale cancer.
Results: In all, 66 patients were included for analysis. A total of 7 patients (10.6 %) had positive lymph nodes on histology examination when PET-CT was negative. Three patients had positive pelvic PET-CT whereas the 4 remaining patients had a negative pelvic PET-CT.
Conclusion: 10.6 % of patients with negative para-aortic PET-CT had positive histology results. There was no significant difference between the para-aortic histological results depending on the pelvic PET-CT results. The PAROLA study, which is currently being recruited, should provide an answer to the question of the benefit of lumbo-aortic lymph node dissection on recurrence-free survival at 3 years.
(Copyright © 2025. Published by Elsevier Masson SAS.)