4-azasteroids, 4-azapregnenes, aldol condensation, molecular docking, antiproliferative activity, Paracaudina chilensis, Molpadida, triterpene glycosides, chilensosides, sea cucumber, cytotoxic activity, 26-thiodiosgenin, thiol oxidation, sulfoxides, sulfones, sapogenins, steroids, antimicrobial activity, cytotoxicity, breast cancer, endocrine therapy, endocrine resistance, aromatase inhibitors, exemestane, oxymestane, anti-cancer properties, multi-target compounds, aromatase, estrogen receptor, androgen receptor, Chan–Lam reaction, diaryl ether, 13α-estrone, antiproliferative effect, tubulin polymerization, molecular dynamics, oximes, chemistry, antitumor, anti-inflammatory, antibacterial, antifungal, antiviral, triterpenoids, isoprenoid lipids, anti-neoplastic, anti-fungal, anti-bacterial, anti-viral, fungal endophytes, plants, marine invertebrates, furanosteroids, fungi, marine organisms, diacetoxy-5α-cholestane, crystal structure HSA binding, multi-spectroscopy, DFT, steroid dimers, 1,4-phenylene-linked dimers, montmorillonite, DHEA, cholesterol, cation channels, TRPML1, bioisostere, estrogens, ring cleavage, protective groups, pyridines, pyrimidines, cyclization, antimetabolites, cell growth inhibition, gene expression, HeLa cells, in vitro culture, Research and information: general, Biology, life sciences

Steroids are a large group of compounds whose structure is based on a 17-carbon skeleton, with a specific cyclopentanoperhydrophenanthrene ring system. Natural steroids have been fine-tuned through evolution to build membranes; act as chemical messengers that regulate metabolic, immune and reproductive functions in animals and stimulate the growth of, or otherwise protect, animal organisms. The steroid core represents a suitable motive for structural modifications. Therefore, a large group of semi-synthetic steroid derivatives have occupied the attention of synthetic chemists as well as medicinal chemists due to their potential biological activity, including anticancer, antibacterial, anti-inflammatory and (anti)hormonal activities.This Reprint of the Special Issue of Molecules titled “Steroid Compounds with Potential Biological Activity” is dedicated to both experimental and theoretical studies on steroid chemistry, structural biology, biosynthesis, metabolism, and pharmacology. The Issue focuses on the isolation and synthesis of steroid compounds, diverse in origin, as well as their structural characterization and identification. Published articles and reviews relate to in vitro and in silico studies of the pharmacological properties, molecular biology, biochemistry and structural biology of steroids.