pyrazolopyridopyridazine dione, N-aminopyrazolopyrrolopyridine dione, luminol, photoluminescence, pyrazole, coumarin, antimicrobial, hydrazone, biofilm, Staphylococcus aureus, S. epidermidis, MRSA, pyrazolyl-ureas, pyrazole nucleus, protein kinase inhibitors, anti-inflammatory agents, anticancer agents, anti-pathogens agents, nitrated pyrazoles-based, energetic salts, synthesis, high energy density material, insensitivity, amination, 4-halopyrazole, Buchwald-Hartwig coupling, Pd(dba)2, CuI mediated coupling, aliphatic amine, X-ray, pyrazolate, coinage metals, metallacycles, M06-2x, pyrazolyl-s-triazine, Fe(III), self-assembly, Hirshfeld, antimicrobial activity, pyrazoles, styrylpyrazoles, biological activity, organic synthesis, reactivity, homocoupling, bipyrazole, transition-metal catalysts, metal–organic frameworks, 1,3-dipolar cycloadditions, 2,3-dihydropyrazolo[1,2-a]pyrazoles, copper-catalyzed azomethine imine-alkyne cycloaddition (CuAIAC), azomethine imines, ynones, bis(pyrazol-1-yl)alkanes, carboxylation, oxalyl chloride, dicarboxylic acids, alkylation, superbasic medium, 1,2,4-oxadiazoles, spiropyrazolinium compounds, in vitro antitubercular screening, X-ray diffraction, molecular docking, polynuclear, silver, crystal structure, pyrazolate ligand, coordination polymer, functionalization, heterocyclic, neurodegeneration, Alzheimer’s disease, Parkinson’s disease, inhibitor, antagonist, antitumor scaffold, enzymatic inhibitory, N-heterocyclic compounds, pyrazolo[1,5-a]pyrimidine, pyrazolo[1,5-a]pyrimidines, aromatic substitution, electrooxidation, C–H halogenation, C–H thiocyanation, N–N coupling, cyclic voltammetry, Research and information: general, Chemistry, Organic chemistry

Pyrazoles and their reduced form, pyrazolines, are considered privileged scaffolds in medicinal chemistry, owing to their noteworthy biological activities, physicochemical properties and occurrence in many low-molecular-weight compounds present in several marketed drugs (e.g., Celebrex® and Viagra®). Pyrazoles are also found in a variety of agrochemicals (fungicides, insecticides, and herbicides) and are versatile compounds for synthetic manipulations. Their challenging chemical structures and properties (mainly tautomerism, with possible implications in their reactivity), and diverse applications, have attracted the attention of many researchers who have developed various synthetic approaches. This reprint presents some examples of the most recent advances in pyrazoles’ chemistry, including synthetic methodologies to access novel pyrazole derivatives, to their functionalization, and studies of their properties and applications in different fields, mainly in medicine and materials science.