split IVF-ICSI, oocyte, SERa, embryological outcomes, clinical and neonatal outcomes, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

ObjectiveTo investigate the impact of smooth endoplasmic reticulum aggregates (SERa) in oocytes on embryological outcomes and clinical and neonatal outcomes during split IVF-ICSI cycles.MethodsA retrospective analysis was conducted using clinical data from January 2020 to December 2023 at the Reproductive Medicine Center of Hainan Women and Children’s Medical Center. Patients were divided into SERa+ and SERa- cycles based on the visibility of SERa after the removal of cumulus cells. Basic patient characteristics, embryological outcomes, clinical and neonatal outcomes were compared between the two groups.ResultsCompared to the SERa- cycles, the SERa+ cycles showed significantly higher levels of E2 on the day of hCG administration (P0.05). No congenital birth defects were found in either group.ConclusionThe occurrence of SERa in split IVF-ICSI cycles may be associated with increased E2 levels on hCG day, and the presence of SERa does not appear to affect in vitro fertilization, embryological, clinical, or neonatal outcomes.