antimicrobial resistance, vancomycin resistance, bacteria, Enterococci faecium, hospital-acquired infection, nosocomial infection, Medicine, Infectious and parasitic diseases, RC109-216

We investigated genomic evolution of vancomycin-resistant Enterococcus faecium (VREF) during an outbreak in Shenzhen, China. Whole-genome sequencing revealed 2 sequence type 80 VREF subpopulations diverging through insertion sequence–mediated recombination. One subpopulation acquired more antimicrobial resistance and carbohydrate metabolism genes. Persistent VREF transmission underscores the need for genomic surveillance to curb spread.