хроническая обструктивная болезнь легких, бронхиальная астма, ишемическая болезнь сердца, артериальная гипертензия, эндотелиальная дисфункция, системное воспаление, chronic obstructive pulmonary disease, bronchial asthma, coronary heart disease, arterial hypertension, endothelial dysfunction, systemic inflammation, Medicine

A correlation analysis to identify the relationship between markers of endothelial dysfunction (coefficient of endothelial function - EFC, type C natriuretic peptide, endothelin-1) and indicators reflecting the activity of inflammation (C - reactive protein, fractalkine) in patients with chronic obstructive pulmonary disease (COPD), bronchial asthma (BA), coronary heart disease (CHD), arterial hypertension (AH) and in patients with comorbidity (COPD+CHD, COPD+AH, BA+ CHD, BA+AH). It was revealed that at comorbid combinations COPD+AG, BA+AG basic mechanism of development of endothelial dysfunction is the activation of chemotactic inflammatory cascade with hyperproduction of fractalkine. C-reactive protein, fractalkine are diagnostic and prognostic markers defeat of endothelium in patients with combinations of COPD+ CHD, BA+CHD.