Регуляторные исследования и экспертиза лекарственных средств, Vol 7, Iss 1, Pp 15-19 (2018)

Federal State Budgetary Institution ‘Scientific Centre for Expert Evaluation of Medicinal Products’ of the Ministry of Health of the Russian Federation (FSBI ‘SCEEMP’), 2018.

рифампицин, рифабутин, депрессорные вещества, гистамин, сердечно-сосудистая система, артериальное давление, rifampicin, rifabutin, depressor substances, histamine, cardiovascular system, blood pressure, Medicine (General), R5-920

The article summarises the results of a study which assessed the response of the cardiovascular system of cats to intravenous administration of the ansamycin class of antibiotics using commercial samples and investigational samples of rifampicin and rifabutin for injections. It was shown that intravenous administration of ansamycin solutions was accompanied by hypotensive effects of varying severity. The increase in the rate of rifampicin administration at a dose of 2.0 mg/0.5 ml/kg can result in a greater decrease of the cat’s blood pressure as compared to the effect caused by the administration of the same dose at a rate described in the monograph 1.2.4.0008.15 «Test for depressor substances». Based on the results of the study a mechanism underlying the observed effect was suggested.