Parkinson’s disease, early detection, digital medical detection, deep learning, smartphone walking recording, Medical technology, R855-855.5, Therapeutics. Pharmacology, RM1-950

With the development of digital medical technology, ubiquitous smartphones are emerging as valuable tools for the detection of complex and elusive diseases. This paper exploits smartphone walking recording for early detection of Parkinson’s disease (PD) and finds that walking recording empowered by deep learning is a valid digital biomarker for early-recognizing PD patients. Specifically, the inertial sensor data is preprocessed, including normalization, scaling, and rotation, and then the processed data is fed into the proposed deep NeuroEnhanceNet. Finally, determine the individual prediction score using the PD-prone strategy and generate the detection results. The proposed deep NeuroEnhanceNet, specifically designed for inertial sensor data, can focus on both the long-term data characteristics within a single channel and the inter-channel correlations. Our method obtains a low false negative rate of 0.053 for the early detection of PD. We further analyze and compare the effectiveness of digital biomarkers captured from the walking and resting processes for early detection of PD. All the code for this work is available at: Visa.